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Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia
Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341312/ https://www.ncbi.nlm.nih.gov/pubmed/30687065 http://dx.doi.org/10.1159/000495032 |
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author | Pan, Elizabeth Hsieh, Eric Piatek, Caroline |
author_facet | Pan, Elizabeth Hsieh, Eric Piatek, Caroline |
author_sort | Pan, Elizabeth |
collection | PubMed |
description | Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Oxaliplatin is a platinum derivative commonly used in gastrointestinal malignancies and is associated with drug-induced immune thrombocytopenia. |
format | Online Article Text |
id | pubmed-6341312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-63413122019-01-25 Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia Pan, Elizabeth Hsieh, Eric Piatek, Caroline Case Rep Oncol Case Report Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Oxaliplatin is a platinum derivative commonly used in gastrointestinal malignancies and is associated with drug-induced immune thrombocytopenia. S. Karger AG 2018-12-20 /pmc/articles/PMC6341312/ /pubmed/30687065 http://dx.doi.org/10.1159/000495032 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Pan, Elizabeth Hsieh, Eric Piatek, Caroline Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title | Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title_full | Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title_fullStr | Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title_full_unstemmed | Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title_short | Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia |
title_sort | case report: oxaliplatin-induced immune-mediated thrombocytopenia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341312/ https://www.ncbi.nlm.nih.gov/pubmed/30687065 http://dx.doi.org/10.1159/000495032 |
work_keys_str_mv | AT panelizabeth casereportoxaliplatininducedimmunemediatedthrombocytopenia AT hsieheric casereportoxaliplatininducedimmunemediatedthrombocytopenia AT piatekcaroline casereportoxaliplatininducedimmunemediatedthrombocytopenia |