CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines

Dysregulated expression of the cell surface protein, CD146, has been implicated in various types of cancer in humans, including in lung cancer. The present study aimed to clarify the mechanism underlying abnormal CD146 expression in human pulmonary large cell neuroendocrine carcinoma (LCNEC) cell li...

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Autores principales: Piao, Yicui, Guo, Hongyu, Qu, Zhibo, Zheng, Biao, Gao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341587/
https://www.ncbi.nlm.nih.gov/pubmed/30675274
http://dx.doi.org/10.3892/ol.2018.9830
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author Piao, Yicui
Guo, Hongyu
Qu, Zhibo
Zheng, Biao
Gao, Yong
author_facet Piao, Yicui
Guo, Hongyu
Qu, Zhibo
Zheng, Biao
Gao, Yong
author_sort Piao, Yicui
collection PubMed
description Dysregulated expression of the cell surface protein, CD146, has been implicated in various types of cancer in humans, including in lung cancer. The present study aimed to clarify the mechanism underlying abnormal CD146 expression in human pulmonary large cell neuroendocrine carcinoma (LCNEC) cell lines (NCI-H460 and NCI-H810). The functions of CD146 were investigated by measuring cell migration and viability following CD146 knockdown or overexpression via small interference RNA and plasmid transfection. The findings demonstrated that decreased protein expression of CD146 could inhibit migration and viability in LCNEC cells. Furthermore, CD146 was determined to influence the expression of epithelial-mesenchymal transition markers (epithelial cadherin, vimentin and Snail) and promoted AKT phosphorylation. The present results imply CD146 may function in the migration and proliferation of pulmonary LCNEC cells.
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spelling pubmed-63415872019-01-23 CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines Piao, Yicui Guo, Hongyu Qu, Zhibo Zheng, Biao Gao, Yong Oncol Lett Articles Dysregulated expression of the cell surface protein, CD146, has been implicated in various types of cancer in humans, including in lung cancer. The present study aimed to clarify the mechanism underlying abnormal CD146 expression in human pulmonary large cell neuroendocrine carcinoma (LCNEC) cell lines (NCI-H460 and NCI-H810). The functions of CD146 were investigated by measuring cell migration and viability following CD146 knockdown or overexpression via small interference RNA and plasmid transfection. The findings demonstrated that decreased protein expression of CD146 could inhibit migration and viability in LCNEC cells. Furthermore, CD146 was determined to influence the expression of epithelial-mesenchymal transition markers (epithelial cadherin, vimentin and Snail) and promoted AKT phosphorylation. The present results imply CD146 may function in the migration and proliferation of pulmonary LCNEC cells. D.A. Spandidos 2019-02 2018-12-14 /pmc/articles/PMC6341587/ /pubmed/30675274 http://dx.doi.org/10.3892/ol.2018.9830 Text en Copyright: © Piao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Piao, Yicui
Guo, Hongyu
Qu, Zhibo
Zheng, Biao
Gao, Yong
CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title_full CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title_fullStr CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title_full_unstemmed CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title_short CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
title_sort cd146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341587/
https://www.ncbi.nlm.nih.gov/pubmed/30675274
http://dx.doi.org/10.3892/ol.2018.9830
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