Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

BACKGROUND: Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the AVX001 and AVX002 cPLA2α inhibitors were investigated. METHODS: In vitro enzyme...

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Detalles Bibliográficos
Autores principales: Feuerherm, A. J., Dennis, E. A., Johansen, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341602/
https://www.ncbi.nlm.nih.gov/pubmed/30665457
http://dx.doi.org/10.1186/s13075-018-1794-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341602/
https://www.ncbi.nlm.nih.gov/pubmed/30665457
http://dx.doi.org/10.1186/s13075-018-1794-6

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