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Dementia with Lewy bodies: an update and outlook
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neuri...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341685/ https://www.ncbi.nlm.nih.gov/pubmed/30665447 http://dx.doi.org/10.1186/s13024-019-0306-8 |
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author | Outeiro, Tiago Fleming Koss, David J. Erskine, Daniel Walker, Lauren Kurzawa-Akanbi, Marzena Burn, David Donaghy, Paul Morris, Christopher Taylor, John-Paul Thomas, Alan Attems, Johannes McKeith, Ian |
author_facet | Outeiro, Tiago Fleming Koss, David J. Erskine, Daniel Walker, Lauren Kurzawa-Akanbi, Marzena Burn, David Donaghy, Paul Morris, Christopher Taylor, John-Paul Thomas, Alan Attems, Johannes McKeith, Ian |
author_sort | Outeiro, Tiago Fleming |
collection | PubMed |
description | Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies. |
format | Online Article Text |
id | pubmed-6341685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63416852019-01-24 Dementia with Lewy bodies: an update and outlook Outeiro, Tiago Fleming Koss, David J. Erskine, Daniel Walker, Lauren Kurzawa-Akanbi, Marzena Burn, David Donaghy, Paul Morris, Christopher Taylor, John-Paul Thomas, Alan Attems, Johannes McKeith, Ian Mol Neurodegener Review Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies. BioMed Central 2019-01-21 /pmc/articles/PMC6341685/ /pubmed/30665447 http://dx.doi.org/10.1186/s13024-019-0306-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Outeiro, Tiago Fleming Koss, David J. Erskine, Daniel Walker, Lauren Kurzawa-Akanbi, Marzena Burn, David Donaghy, Paul Morris, Christopher Taylor, John-Paul Thomas, Alan Attems, Johannes McKeith, Ian Dementia with Lewy bodies: an update and outlook |
title | Dementia with Lewy bodies: an update and outlook |
title_full | Dementia with Lewy bodies: an update and outlook |
title_fullStr | Dementia with Lewy bodies: an update and outlook |
title_full_unstemmed | Dementia with Lewy bodies: an update and outlook |
title_short | Dementia with Lewy bodies: an update and outlook |
title_sort | dementia with lewy bodies: an update and outlook |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341685/ https://www.ncbi.nlm.nih.gov/pubmed/30665447 http://dx.doi.org/10.1186/s13024-019-0306-8 |
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