Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

BACKGROUND: We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection with little toxicity. Since the highest efficiency of INTERFERin (INT), a cationi...

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Detalles Bibliográficos
Autores principales: Kasai, Hironori, Inoue, Kenji, Imamura, Kentaro, Yuvienco, Carlo, Montclare, Jin K., Yamano, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341701/
https://www.ncbi.nlm.nih.gov/pubmed/30670041
http://dx.doi.org/10.1186/s12951-019-0444-8

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