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Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma

Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcino...

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Autores principales: Wang, Gang, Pan, Jingen, Zhang, Lu, Wang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341798/
https://www.ncbi.nlm.nih.gov/pubmed/30675204
http://dx.doi.org/10.3892/ol.2018.9741
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author Wang, Gang
Pan, Jingen
Zhang, Lu
Wang, Cheng
author_facet Wang, Gang
Pan, Jingen
Zhang, Lu
Wang, Cheng
author_sort Wang, Gang
collection PubMed
description Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcinoma (PC). The aim of the present study was to investigate the expression of GRHL2 in PC and to evaluate its clinicopathological and prognostic significance. Immunohistochemistry and western blotting were used to detect the expression of GRHL2 in PC tissues and cell lines, respectively. The expression of GRHL2 was investigated in 92 PC tissue samples by immunohistochemistry. High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024). A Kaplan-Meier analysis revealed that high expression of GRHL2 was associated with worsened overall survival time (P<0.001). Multivariate analysis indicated that GRHL2 may be an independent prognostic factor for poor overall survival time (P=0.001). Additionally, western blot analysis demonstrated that the GRHL2 protein was highly expressed in PC cell lines. GRHL2 may serve an important role in the tumourigenesis of PC and serve as a potential therapeutic target for the prevention of PC progression.
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spelling pubmed-63417982019-01-23 Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma Wang, Gang Pan, Jingen Zhang, Lu Wang, Cheng Oncol Lett Articles Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcinoma (PC). The aim of the present study was to investigate the expression of GRHL2 in PC and to evaluate its clinicopathological and prognostic significance. Immunohistochemistry and western blotting were used to detect the expression of GRHL2 in PC tissues and cell lines, respectively. The expression of GRHL2 was investigated in 92 PC tissue samples by immunohistochemistry. High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024). A Kaplan-Meier analysis revealed that high expression of GRHL2 was associated with worsened overall survival time (P<0.001). Multivariate analysis indicated that GRHL2 may be an independent prognostic factor for poor overall survival time (P=0.001). Additionally, western blot analysis demonstrated that the GRHL2 protein was highly expressed in PC cell lines. GRHL2 may serve an important role in the tumourigenesis of PC and serve as a potential therapeutic target for the prevention of PC progression. D.A. Spandidos 2019-02 2018-11-21 /pmc/articles/PMC6341798/ /pubmed/30675204 http://dx.doi.org/10.3892/ol.2018.9741 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Gang
Pan, Jingen
Zhang, Lu
Wang, Cheng
Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title_full Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title_fullStr Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title_full_unstemmed Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title_short Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
title_sort overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341798/
https://www.ncbi.nlm.nih.gov/pubmed/30675204
http://dx.doi.org/10.3892/ol.2018.9741
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