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Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcino...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341798/ https://www.ncbi.nlm.nih.gov/pubmed/30675204 http://dx.doi.org/10.3892/ol.2018.9741 |
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author | Wang, Gang Pan, Jingen Zhang, Lu Wang, Cheng |
author_facet | Wang, Gang Pan, Jingen Zhang, Lu Wang, Cheng |
author_sort | Wang, Gang |
collection | PubMed |
description | Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcinoma (PC). The aim of the present study was to investigate the expression of GRHL2 in PC and to evaluate its clinicopathological and prognostic significance. Immunohistochemistry and western blotting were used to detect the expression of GRHL2 in PC tissues and cell lines, respectively. The expression of GRHL2 was investigated in 92 PC tissue samples by immunohistochemistry. High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024). A Kaplan-Meier analysis revealed that high expression of GRHL2 was associated with worsened overall survival time (P<0.001). Multivariate analysis indicated that GRHL2 may be an independent prognostic factor for poor overall survival time (P=0.001). Additionally, western blot analysis demonstrated that the GRHL2 protein was highly expressed in PC cell lines. GRHL2 may serve an important role in the tumourigenesis of PC and serve as a potential therapeutic target for the prevention of PC progression. |
format | Online Article Text |
id | pubmed-6341798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-63417982019-01-23 Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma Wang, Gang Pan, Jingen Zhang, Lu Wang, Cheng Oncol Lett Articles Recent studies have demonstrated that the abnormal expression of the grainyhead-like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcinoma (PC). The aim of the present study was to investigate the expression of GRHL2 in PC and to evaluate its clinicopathological and prognostic significance. Immunohistochemistry and western blotting were used to detect the expression of GRHL2 in PC tissues and cell lines, respectively. The expression of GRHL2 was investigated in 92 PC tissue samples by immunohistochemistry. High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024). A Kaplan-Meier analysis revealed that high expression of GRHL2 was associated with worsened overall survival time (P<0.001). Multivariate analysis indicated that GRHL2 may be an independent prognostic factor for poor overall survival time (P=0.001). Additionally, western blot analysis demonstrated that the GRHL2 protein was highly expressed in PC cell lines. GRHL2 may serve an important role in the tumourigenesis of PC and serve as a potential therapeutic target for the prevention of PC progression. D.A. Spandidos 2019-02 2018-11-21 /pmc/articles/PMC6341798/ /pubmed/30675204 http://dx.doi.org/10.3892/ol.2018.9741 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Gang Pan, Jingen Zhang, Lu Wang, Cheng Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title | Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title_full | Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title_fullStr | Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title_full_unstemmed | Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title_short | Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
title_sort | overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341798/ https://www.ncbi.nlm.nih.gov/pubmed/30675204 http://dx.doi.org/10.3892/ol.2018.9741 |
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