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MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma

MicroRNAs (miRNAs) serve an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR-197-3p has been reported in various human malignancies. However, the role of miR-197-3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. The p...

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Autores principales: Ni, Jun-Sheng, Zheng, Hao, Huang, Zhi-Ping, Hong, Yong-Gang, Ou, Yang-Liu, Tao, Yuan-Ping, Wang, Meng-Chao, Wang, Zhen-Guang, Yang, Yuan, Zhou, Wei-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341871/
https://www.ncbi.nlm.nih.gov/pubmed/30675297
http://dx.doi.org/10.3892/ol.2018.9848
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author Ni, Jun-Sheng
Zheng, Hao
Huang, Zhi-Ping
Hong, Yong-Gang
Ou, Yang-Liu
Tao, Yuan-Ping
Wang, Meng-Chao
Wang, Zhen-Guang
Yang, Yuan
Zhou, Wei-Ping
author_facet Ni, Jun-Sheng
Zheng, Hao
Huang, Zhi-Ping
Hong, Yong-Gang
Ou, Yang-Liu
Tao, Yuan-Ping
Wang, Meng-Chao
Wang, Zhen-Guang
Yang, Yuan
Zhou, Wei-Ping
author_sort Ni, Jun-Sheng
collection PubMed
description MicroRNAs (miRNAs) serve an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR-197-3p has been reported in various human malignancies. However, the role of miR-197-3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. The present study demonstrated that miR-197-3p was downregulated in HCC tissues and that the low level of miR-197-3p expression in HCC tumours correlated with aggressive clinicopathological characteristics; thus, miR-197-3p may serve as a predictor for poor prognosis in patients with HCC. Additionally, miR-197-3p markedly inhibited the metastasis of HCC cells in vitro and in vivo. Bioinformatics analysis further identified zinc finger protein interacted with K protein 1 (ZIK1) as a novel target of miR-197-3p in HCC cells. These findings suggest that miR-197-3p may regulate the survival of HCC cells, partially through the downregulation of ZIK1. Therefore, the miR-197-3p/ZIK1 axis may serve as a novel therapeutic target in patients with HCC.
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spelling pubmed-63418712019-01-23 MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma Ni, Jun-Sheng Zheng, Hao Huang, Zhi-Ping Hong, Yong-Gang Ou, Yang-Liu Tao, Yuan-Ping Wang, Meng-Chao Wang, Zhen-Guang Yang, Yuan Zhou, Wei-Ping Oncol Lett Articles MicroRNAs (miRNAs) serve an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR-197-3p has been reported in various human malignancies. However, the role of miR-197-3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. The present study demonstrated that miR-197-3p was downregulated in HCC tissues and that the low level of miR-197-3p expression in HCC tumours correlated with aggressive clinicopathological characteristics; thus, miR-197-3p may serve as a predictor for poor prognosis in patients with HCC. Additionally, miR-197-3p markedly inhibited the metastasis of HCC cells in vitro and in vivo. Bioinformatics analysis further identified zinc finger protein interacted with K protein 1 (ZIK1) as a novel target of miR-197-3p in HCC cells. These findings suggest that miR-197-3p may regulate the survival of HCC cells, partially through the downregulation of ZIK1. Therefore, the miR-197-3p/ZIK1 axis may serve as a novel therapeutic target in patients with HCC. D.A. Spandidos 2019-02 2018-12-18 /pmc/articles/PMC6341871/ /pubmed/30675297 http://dx.doi.org/10.3892/ol.2018.9848 Text en Copyright: © Ni et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Ni, Jun-Sheng
Zheng, Hao
Huang, Zhi-Ping
Hong, Yong-Gang
Ou, Yang-Liu
Tao, Yuan-Ping
Wang, Meng-Chao
Wang, Zhen-Guang
Yang, Yuan
Zhou, Wei-Ping
MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title_full MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title_fullStr MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title_full_unstemmed MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title_short MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
title_sort microrna-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341871/
https://www.ncbi.nlm.nih.gov/pubmed/30675297
http://dx.doi.org/10.3892/ol.2018.9848
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