Cargando…
Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study
BACKGROUND: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear. OBJECTIVE: This study investigated...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342150/ https://www.ncbi.nlm.nih.gov/pubmed/30697053 http://dx.doi.org/10.2147/NDT.S189962 |
_version_ | 1783389081746538496 |
---|---|
author | Yang, Jun Li, Bin Yu, Qiu-Yue Ye, Lei Zhu, Pei-Wen Shi, Wen-Qing Yuan, Qing Min, You-Lan He, Yu-Lin Shao, Yi |
author_facet | Yang, Jun Li, Bin Yu, Qiu-Yue Ye, Lei Zhu, Pei-Wen Shi, Wen-Qing Yuan, Qing Min, You-Lan He, Yu-Lin Shao, Yi |
author_sort | Yang, Jun |
collection | PubMed |
description | BACKGROUND: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear. OBJECTIVE: This study investigated intrinsic brain activity changes in TA subjects using the amplitude of low-frequency fluctuation (ALFF) technique. METHODS: A total of 18 patients with TA (eight males, and 10 females) and 18 healthy controls (HCs) who were matched for gender, age, and educational status were enrolled. Resting-state functional MRI was used to examine the participants. Spontaneous cerebral activity variations were investigated using the ALFF technique. The mean ALFF values of the TA patients and the HCs were classified using receiver operating characteristic (ROC) curves. The correlations between ALFF signals of distinct regions of the cerebrum and the clinical manifestations of the TA patients were evaluated using Pearson’s correlation analysis. RESULTS: Compared with HCs, TA patients showed notably higher ALFF in the left postcentral gyrus, right paracentral lobule, right lingual gyrus, right inferior occipital gyrus, left fusiform gyrus, and right superior occipital gyrus. ROC curve analysis of each brain region showed that the accuracy area under the curve was excellent. In the TA group, the visual analog scale of the left side was positively correlated with the ALFF signal values of the right paracentral lobule (r=0.639, P=0.025). CONCLUSION: Multiple brain regions, including pain- and vision-related areas, exhibited aberrant intrinsic brain activity patterns, which may help to explain the underlying neural mechanisms in TA. |
format | Online Article Text |
id | pubmed-6342150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63421502019-01-29 Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study Yang, Jun Li, Bin Yu, Qiu-Yue Ye, Lei Zhu, Pei-Wen Shi, Wen-Qing Yuan, Qing Min, You-Lan He, Yu-Lin Shao, Yi Neuropsychiatr Dis Treat Original Research BACKGROUND: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear. OBJECTIVE: This study investigated intrinsic brain activity changes in TA subjects using the amplitude of low-frequency fluctuation (ALFF) technique. METHODS: A total of 18 patients with TA (eight males, and 10 females) and 18 healthy controls (HCs) who were matched for gender, age, and educational status were enrolled. Resting-state functional MRI was used to examine the participants. Spontaneous cerebral activity variations were investigated using the ALFF technique. The mean ALFF values of the TA patients and the HCs were classified using receiver operating characteristic (ROC) curves. The correlations between ALFF signals of distinct regions of the cerebrum and the clinical manifestations of the TA patients were evaluated using Pearson’s correlation analysis. RESULTS: Compared with HCs, TA patients showed notably higher ALFF in the left postcentral gyrus, right paracentral lobule, right lingual gyrus, right inferior occipital gyrus, left fusiform gyrus, and right superior occipital gyrus. ROC curve analysis of each brain region showed that the accuracy area under the curve was excellent. In the TA group, the visual analog scale of the left side was positively correlated with the ALFF signal values of the right paracentral lobule (r=0.639, P=0.025). CONCLUSION: Multiple brain regions, including pain- and vision-related areas, exhibited aberrant intrinsic brain activity patterns, which may help to explain the underlying neural mechanisms in TA. Dove Medical Press 2019-01-18 /pmc/articles/PMC6342150/ /pubmed/30697053 http://dx.doi.org/10.2147/NDT.S189962 Text en © 2019 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yang, Jun Li, Bin Yu, Qiu-Yue Ye, Lei Zhu, Pei-Wen Shi, Wen-Qing Yuan, Qing Min, You-Lan He, Yu-Lin Shao, Yi Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title | Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title_full | Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title_fullStr | Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title_full_unstemmed | Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title_short | Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study |
title_sort | altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fmri study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342150/ https://www.ncbi.nlm.nih.gov/pubmed/30697053 http://dx.doi.org/10.2147/NDT.S189962 |
work_keys_str_mv | AT yangjun alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT libin alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT yuqiuyue alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT yelei alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT zhupeiwen alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT shiwenqing alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT yuanqing alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT minyoulan alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT heyulin alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy AT shaoyi alteredintrinsicbrainactivityinpatientswithtoothachesusingtheamplitudeoflowfrequencyfluctuationsarestingstatefmristudy |