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Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy

Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. However, simple optical hypoxia imaging is not enough for tumor diagnosis. Also, the tum...

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Detalles Bibliográficos
Autores principales: Liu, Jiajun, Liu, Zeying, Wu, Daocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342223/
https://www.ncbi.nlm.nih.gov/pubmed/30705587
http://dx.doi.org/10.2147/IJN.S192048
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author Liu, Jiajun
Liu, Zeying
Wu, Daocheng
author_facet Liu, Jiajun
Liu, Zeying
Wu, Daocheng
author_sort Liu, Jiajun
collection PubMed
description Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. However, simple optical hypoxia imaging is not enough for tumor diagnosis. Also, the tumor therapy process needs the information about the tumor hypoxia condition. Recently, researchers developed multimodal hypoxia tumor imaging nanoparticles and multifunctional hypoxia imaging-guided tumor therapy nanoparticles. The multimodal hypoxia imaging could produce more tumor region information and engage in functional tumor imaging to better understand the tumor condition. The multifunctional hypoxia imaging-guided tumor therapy could monitor the tumor therapy process and evaluate tumor therapeutic effect. Meanwhile, many challenges and limitations are still remaining in the application of multifunctional hypoxia nanoparticles. In this review, we first introduce the types of multifunctional hypoxia imaging nanoparticles. Then we focus on multimodal hypoxia imaging nanoparticles and hypoxia imaging-guided tumor therapy nanoparticles. We also discuss the challenges and future perspectives of this field. There has not been many studies in this field for now. We hope this review would bring more researchers’ attention to this field so that it would substantially contribute to tumor precise therapy.
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spelling pubmed-63422232019-01-31 Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy Liu, Jiajun Liu, Zeying Wu, Daocheng Int J Nanomedicine Review Hypoxia is a common feature of most solid tumors. Having a comprehensive understanding of tumor hypoxia condition is a key to tumor therapy. Many hypoxia imaging nanoparticles have been used for tumor detection. However, simple optical hypoxia imaging is not enough for tumor diagnosis. Also, the tumor therapy process needs the information about the tumor hypoxia condition. Recently, researchers developed multimodal hypoxia tumor imaging nanoparticles and multifunctional hypoxia imaging-guided tumor therapy nanoparticles. The multimodal hypoxia imaging could produce more tumor region information and engage in functional tumor imaging to better understand the tumor condition. The multifunctional hypoxia imaging-guided tumor therapy could monitor the tumor therapy process and evaluate tumor therapeutic effect. Meanwhile, many challenges and limitations are still remaining in the application of multifunctional hypoxia nanoparticles. In this review, we first introduce the types of multifunctional hypoxia imaging nanoparticles. Then we focus on multimodal hypoxia imaging nanoparticles and hypoxia imaging-guided tumor therapy nanoparticles. We also discuss the challenges and future perspectives of this field. There has not been many studies in this field for now. We hope this review would bring more researchers’ attention to this field so that it would substantially contribute to tumor precise therapy. Dove Medical Press 2019-01-18 /pmc/articles/PMC6342223/ /pubmed/30705587 http://dx.doi.org/10.2147/IJN.S192048 Text en © 2019 Liu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Liu, Jiajun
Liu, Zeying
Wu, Daocheng
Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_full Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_fullStr Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_full_unstemmed Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_short Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
title_sort multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342223/
https://www.ncbi.nlm.nih.gov/pubmed/30705587
http://dx.doi.org/10.2147/IJN.S192048
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