Assessment of CYP‐Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in Humans

Evocalcet is a novel calcimimetic agent for the treatment of secondary hyperparathyroidism (SHPT). This study evaluated the effects of evocalcet on inhibition and induction of cytochrome P450 (CYP) isozymes. Although drug interactions arising from reversible inhibition of CYP isozymes by evocalcet w...

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Detalles Bibliográficos
Autores principales: Narushima, Kazuya, Maeda, Hiroshi, Shiramoto, Masanari, Endo, Yuichi, Ohtsuka, Satoko, Nakamura, Hiroaki, Nagata, Yoshinori, Uchimura, Tatsuo, Kannami, Ayako, Shimazaki, Ryutaro, Fukagawa, Masafumi, Akizawa, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342237/
https://www.ncbi.nlm.nih.gov/pubmed/30238620
http://dx.doi.org/10.1111/cts.12588

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