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Thalamic reticular control of local sleep in mouse sensory cortex

Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cor...

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Autores principales: Fernandez, Laura MJ, Vantomme, Gil, Osorio-Forero, Alejandro, Cardis, Romain, Béard, Elidie, Lüthi, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342525/
https://www.ncbi.nlm.nih.gov/pubmed/30583750
http://dx.doi.org/10.7554/eLife.39111
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author Fernandez, Laura MJ
Vantomme, Gil
Osorio-Forero, Alejandro
Cardis, Romain
Béard, Elidie
Lüthi, Anita
author_facet Fernandez, Laura MJ
Vantomme, Gil
Osorio-Forero, Alejandro
Cardis, Romain
Béard, Elidie
Lüthi, Anita
author_sort Fernandez, Laura MJ
collection PubMed
description Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca(2+) channel Ca(V)3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca(V)3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca(V)3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence.
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spelling pubmed-63425252019-01-24 Thalamic reticular control of local sleep in mouse sensory cortex Fernandez, Laura MJ Vantomme, Gil Osorio-Forero, Alejandro Cardis, Romain Béard, Elidie Lüthi, Anita eLife Neuroscience Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca(2+) channel Ca(V)3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca(V)3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca(V)3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence. eLife Sciences Publications, Ltd 2018-12-25 /pmc/articles/PMC6342525/ /pubmed/30583750 http://dx.doi.org/10.7554/eLife.39111 Text en © 2018, Fernandez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Fernandez, Laura MJ
Vantomme, Gil
Osorio-Forero, Alejandro
Cardis, Romain
Béard, Elidie
Lüthi, Anita
Thalamic reticular control of local sleep in mouse sensory cortex
title Thalamic reticular control of local sleep in mouse sensory cortex
title_full Thalamic reticular control of local sleep in mouse sensory cortex
title_fullStr Thalamic reticular control of local sleep in mouse sensory cortex
title_full_unstemmed Thalamic reticular control of local sleep in mouse sensory cortex
title_short Thalamic reticular control of local sleep in mouse sensory cortex
title_sort thalamic reticular control of local sleep in mouse sensory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342525/
https://www.ncbi.nlm.nih.gov/pubmed/30583750
http://dx.doi.org/10.7554/eLife.39111
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