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Thalamic reticular control of local sleep in mouse sensory cortex
Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342525/ https://www.ncbi.nlm.nih.gov/pubmed/30583750 http://dx.doi.org/10.7554/eLife.39111 |
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author | Fernandez, Laura MJ Vantomme, Gil Osorio-Forero, Alejandro Cardis, Romain Béard, Elidie Lüthi, Anita |
author_facet | Fernandez, Laura MJ Vantomme, Gil Osorio-Forero, Alejandro Cardis, Romain Béard, Elidie Lüthi, Anita |
author_sort | Fernandez, Laura MJ |
collection | PubMed |
description | Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca(2+) channel Ca(V)3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca(V)3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca(V)3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence. |
format | Online Article Text |
id | pubmed-6342525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63425252019-01-24 Thalamic reticular control of local sleep in mouse sensory cortex Fernandez, Laura MJ Vantomme, Gil Osorio-Forero, Alejandro Cardis, Romain Béard, Elidie Lüthi, Anita eLife Neuroscience Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca(2+) channel Ca(V)3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a Ca(V)3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when Ca(V)3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence. eLife Sciences Publications, Ltd 2018-12-25 /pmc/articles/PMC6342525/ /pubmed/30583750 http://dx.doi.org/10.7554/eLife.39111 Text en © 2018, Fernandez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Fernandez, Laura MJ Vantomme, Gil Osorio-Forero, Alejandro Cardis, Romain Béard, Elidie Lüthi, Anita Thalamic reticular control of local sleep in mouse sensory cortex |
title | Thalamic reticular control of local sleep in mouse sensory cortex |
title_full | Thalamic reticular control of local sleep in mouse sensory cortex |
title_fullStr | Thalamic reticular control of local sleep in mouse sensory cortex |
title_full_unstemmed | Thalamic reticular control of local sleep in mouse sensory cortex |
title_short | Thalamic reticular control of local sleep in mouse sensory cortex |
title_sort | thalamic reticular control of local sleep in mouse sensory cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342525/ https://www.ncbi.nlm.nih.gov/pubmed/30583750 http://dx.doi.org/10.7554/eLife.39111 |
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