V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif-encoding light chain genes. Here, we identify an HIV-infected donor with high-titer V2 peptide-binding antibodies and isol...

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Detalles Bibliográficos
Autores principales: van Eeden, Charmaine, Kurt Wibmer, Constantinos, Scheepers, Cathrine, Richardson, Simone I., Nonyane, Molati, Lambson, Bronwen, Mkhize, Nonhlanhla N., Vijayakumar, Balakrishnan, Sheng, Zizhang, Stanfield-Oakley, Sherry, Bhiman, Jinal N., Bekker, Valerie, Hermanus, Tandile, Mabvakure, Batsirai, Ismail, Arshad, Moody, M. Anthony, Wiehe, Kevin, Garrett, Nigel, Karim, Salim Abdool, Dirr, Heini, Fernandes, Manuel A., Sayed, Yasien, Shapiro, Lawrence, Ferrari, Guido, Haynes, Barton F., Moore, Penny L., Morris, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342559/
https://www.ncbi.nlm.nih.gov/pubmed/30540944
http://dx.doi.org/10.1016/j.celrep.2018.11.058

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