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Real-time high-resolution mid-infrared optical coherence tomography
The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been ch...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342823/ https://www.ncbi.nlm.nih.gov/pubmed/30675345 http://dx.doi.org/10.1038/s41377-019-0122-5 |
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author | Israelsen, Niels M. Petersen, Christian R. Barh, Ajanta Jain, Deepak Jensen, Mikkel Hannesschläger, Günther Tidemand-Lichtenberg, Peter Pedersen, Christian Podoleanu, Adrian Bang, Ole |
author_facet | Israelsen, Niels M. Petersen, Christian R. Barh, Ajanta Jain, Deepak Jensen, Mikkel Hannesschläger, Günther Tidemand-Lichtenberg, Peter Pedersen, Christian Podoleanu, Adrian Bang, Ole |
author_sort | Israelsen, Niels M. |
collection | PubMed |
description | The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4 µm and an axial resolution of 8.6 µm is demonstrated. The system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9- to 4.7-µm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-µm bandwidth from 3.58–4.63 µm to 820–865 nm, where a standard 800-nm spectrometer can be used for fast detection. The images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3 μm, and the potential applications and samples suited for this technology are discussed. In doing so, the first practical mid-infrared optical coherence tomography system is demonstrated, with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths. |
format | Online Article Text |
id | pubmed-6342823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63428232019-01-23 Real-time high-resolution mid-infrared optical coherence tomography Israelsen, Niels M. Petersen, Christian R. Barh, Ajanta Jain, Deepak Jensen, Mikkel Hannesschläger, Günther Tidemand-Lichtenberg, Peter Pedersen, Christian Podoleanu, Adrian Bang, Ole Light Sci Appl Article The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4 µm and an axial resolution of 8.6 µm is demonstrated. The system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9- to 4.7-µm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-µm bandwidth from 3.58–4.63 µm to 820–865 nm, where a standard 800-nm spectrometer can be used for fast detection. The images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3 μm, and the potential applications and samples suited for this technology are discussed. In doing so, the first practical mid-infrared optical coherence tomography system is demonstrated, with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths. Nature Publishing Group UK 2019-01-23 /pmc/articles/PMC6342823/ /pubmed/30675345 http://dx.doi.org/10.1038/s41377-019-0122-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Israelsen, Niels M. Petersen, Christian R. Barh, Ajanta Jain, Deepak Jensen, Mikkel Hannesschläger, Günther Tidemand-Lichtenberg, Peter Pedersen, Christian Podoleanu, Adrian Bang, Ole Real-time high-resolution mid-infrared optical coherence tomography |
title | Real-time high-resolution mid-infrared optical coherence tomography |
title_full | Real-time high-resolution mid-infrared optical coherence tomography |
title_fullStr | Real-time high-resolution mid-infrared optical coherence tomography |
title_full_unstemmed | Real-time high-resolution mid-infrared optical coherence tomography |
title_short | Real-time high-resolution mid-infrared optical coherence tomography |
title_sort | real-time high-resolution mid-infrared optical coherence tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342823/ https://www.ncbi.nlm.nih.gov/pubmed/30675345 http://dx.doi.org/10.1038/s41377-019-0122-5 |
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