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Pharmacogenetic clinical randomised phase II trial to evaluate the efficacy and safety of FOLFIRI with high-dose irinotecan (HD-FOLFIRI) in metastatic colorectal cancer patients according to their UGT1A 1 genotype

BACKGROUND: Patients harbouring the UGT1A1*28/*28 genotype are at risk of severe toxicity with the standard irinotecan dose. However, this dose is considerably lower than the dose that can be tolerated by UGT1A1*1/*1 and *1/*28 patients. This randomised phase II trial evaluated the efficacy and safe...

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Detalles Bibliográficos
Autores principales:	Páez, David, Tobeña, María, Fernández-Plana, Julen, Sebio, Ana, Virgili, Anna C., Cirera, Lluís, Barnadas, Agustí, Riera, Pau, Sullivan, Ivana, Salazar, Juliana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342907/ https://www.ncbi.nlm.nih.gov/pubmed/30585257 http://dx.doi.org/10.1038/s41416-018-0348-7

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