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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol,...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342931/ https://www.ncbi.nlm.nih.gov/pubmed/30670697 http://dx.doi.org/10.1038/s41467-018-08008-w |
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| author | Kilpeläinen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupović, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kühnel, Brigitte Laguzzi, Federica Lyytikäinen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickaël Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renée de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayşe Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltán Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Liu, Jianjun Mägi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O’Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, André G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tõnu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimäki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F. |
| author_facet | Kilpeläinen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupović, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kühnel, Brigitte Laguzzi, Federica Lyytikäinen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickaël Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renée de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayşe Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltán Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Liu, Jianjun Mägi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O’Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, André G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tõnu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimäki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F. |
| author_sort | Kilpeläinen, Tuomas O. |
| collection | PubMed |
| description | Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels. |
| format | Online Article Text |
| id | pubmed-6342931 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63429312019-01-24 Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Kilpeläinen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupović, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kühnel, Brigitte Laguzzi, Federica Lyytikäinen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickaël Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renée de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayşe Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltán Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Liu, Jianjun Mägi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O’Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, André G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tõnu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimäki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F. Nat Commun Article Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels. Nature Publishing Group UK 2019-01-22 /pmc/articles/PMC6342931/ /pubmed/30670697 http://dx.doi.org/10.1038/s41467-018-08008-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Kilpeläinen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupović, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kühnel, Brigitte Laguzzi, Federica Lyytikäinen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickaël Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renée de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayşe Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltán Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Liu, Jianjun Mägi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O’Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, André G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tõnu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimäki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title | Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title_full | Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title_fullStr | Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title_full_unstemmed | Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title_short | Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| title_sort | multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342931/ https://www.ncbi.nlm.nih.gov/pubmed/30670697 http://dx.doi.org/10.1038/s41467-018-08008-w |
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multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT uitterlindenandreg multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT vanderendemyldau multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT vanheemstdiana multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT voortmantrudy multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT waldenbergermelanie multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT wennbergpatrik multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT wilsongregory multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT xiangyongbing multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT yaojie 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AT haywardcaroline multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT hortabernardol multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT kellytanikan multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT liuyongmei multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT northkarie multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT pereiraalexandrec multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT ridkerpaulm multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT taieshyong multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT vandamrobm multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT foxervinr multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT kardiasharonlr multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT liuchingti multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT mookkanamoridenniso multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT provincemichaela multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT redlinesusan multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT vanduijncorneliam multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT rotterjeromei multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT kooperbergcharlesb multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT gaudermanwjames multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT psatybrucem multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT ricekenneth multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT munroepatriciab multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT fornagemyriam multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT cupplesladrienne multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT rotimicharlesn multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT morrisonalannac multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT raodabeeruc multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT loosruthjf multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity |