Metabolomic fingerprint of coronary blood in STEMI patients depends on the ischemic time and inflammatory state

In this study we investigated whether the metabolomic analysis could identify a specific fingerprint of coronary blood collected during primary PCI in STEMI patients. Fifteen samples was subjected to metabolomic analysis. Subsequently, the study population was divided into two groups according to th...

Descripción completa

Detalles Bibliográficos
Autores principales: Deidda, Martino, Piras, Cristina, Binaghi, Giulio, Congia, Damiana, Pani, Alessandro, Boi, Alberto, Sanna, Francesco, Rossi, Angelica, Loi, Bruno, Cadeddu Dessalvi, Christian, Atzori, Luigi, Porcu, Maurizio, Mercuro, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342950/
https://www.ncbi.nlm.nih.gov/pubmed/30670713
http://dx.doi.org/10.1038/s41598-018-36415-y
Descripción
Sumario:In this study we investigated whether the metabolomic analysis could identify a specific fingerprint of coronary blood collected during primary PCI in STEMI patients. Fifteen samples was subjected to metabolomic analysis. Subsequently, the study population was divided into two groups according to the peripheral blood neutrophil-to-lymphocyte ratio (NLR), a marker of the systemic inflammatory response. Regression analysis was then applied separately to the two NLR groups. A partial least square (PLS) regression identified the most significant involved metabolites and the PLS-class analysis revealed a significant correlation between the metabolic profile and the total ischemic time only in patients with an NLR > 5.77.

Ejemplares similares