Cargando…
Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis
Accurate risk stratification according to the extent of Langerhans cell histiocytosis (LCH) determined on whole-body evaluation is important for determining the treatment plans and prognosis in patients with LCH. This study aimed to compare the lesion detectability and the accuracy of risk stratific...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342958/ https://www.ncbi.nlm.nih.gov/pubmed/30670752 http://dx.doi.org/10.1038/s41598-018-36501-1 |
_version_ | 1783389188946657280 |
---|---|
author | Kim, Jeong Rye Yoon, Hee Mang Jung, Ah Young Cho, Young Ah Seo, Jong Jin Lee, Jin Seong |
author_facet | Kim, Jeong Rye Yoon, Hee Mang Jung, Ah Young Cho, Young Ah Seo, Jong Jin Lee, Jin Seong |
author_sort | Kim, Jeong Rye |
collection | PubMed |
description | Accurate risk stratification according to the extent of Langerhans cell histiocytosis (LCH) determined on whole-body evaluation is important for determining the treatment plans and prognosis in patients with LCH. This study aimed to compare the lesion detectability and the accuracy of risk stratification of skeletal survey, bone scan, and whole-body magnetic resonance imaging (WB-MRI) in patients with LCH. Patients with newly-diagnosed LCH who underwent all three imaging modalities were retrospectively included (n = 46). The sensitivity and mean number of false-positives per patient for LCH lesions, and the accuracy of risk stratification of each modality were assessed. WB-MRI had significantly higher sensitivity (99.0%; 95% confidence interval, 93.2–99.9%) than skeletal survey (56.6%; p < 0.0001) and bone scan (38.4%; p < 0.0001) for LCH lesions, and there were no significant differences in the number of false-positives per patient (p > 0.017). WB-MRI tended to have higher accuracy for the risk stratification than skeletal survey and bone scan (concordance rate of 0.98, 0.91, and 0.83, respectively), although the differences were not significant (overall p-value 0.066). In conclusion, WB-MRI had higher detectability for LCH lesions than skeletal survey and bone scan, while the three whole-body imaging modalities had comparable accuracy in the initial risk stratification of LCH. |
format | Online Article Text |
id | pubmed-6342958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63429582019-01-25 Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis Kim, Jeong Rye Yoon, Hee Mang Jung, Ah Young Cho, Young Ah Seo, Jong Jin Lee, Jin Seong Sci Rep Article Accurate risk stratification according to the extent of Langerhans cell histiocytosis (LCH) determined on whole-body evaluation is important for determining the treatment plans and prognosis in patients with LCH. This study aimed to compare the lesion detectability and the accuracy of risk stratification of skeletal survey, bone scan, and whole-body magnetic resonance imaging (WB-MRI) in patients with LCH. Patients with newly-diagnosed LCH who underwent all three imaging modalities were retrospectively included (n = 46). The sensitivity and mean number of false-positives per patient for LCH lesions, and the accuracy of risk stratification of each modality were assessed. WB-MRI had significantly higher sensitivity (99.0%; 95% confidence interval, 93.2–99.9%) than skeletal survey (56.6%; p < 0.0001) and bone scan (38.4%; p < 0.0001) for LCH lesions, and there were no significant differences in the number of false-positives per patient (p > 0.017). WB-MRI tended to have higher accuracy for the risk stratification than skeletal survey and bone scan (concordance rate of 0.98, 0.91, and 0.83, respectively), although the differences were not significant (overall p-value 0.066). In conclusion, WB-MRI had higher detectability for LCH lesions than skeletal survey and bone scan, while the three whole-body imaging modalities had comparable accuracy in the initial risk stratification of LCH. Nature Publishing Group UK 2019-01-22 /pmc/articles/PMC6342958/ /pubmed/30670752 http://dx.doi.org/10.1038/s41598-018-36501-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Jeong Rye Yoon, Hee Mang Jung, Ah Young Cho, Young Ah Seo, Jong Jin Lee, Jin Seong Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title | Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title_full | Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title_fullStr | Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title_full_unstemmed | Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title_short | Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis |
title_sort | comparison of whole-body mri, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of langerhans cell histiocytosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342958/ https://www.ncbi.nlm.nih.gov/pubmed/30670752 http://dx.doi.org/10.1038/s41598-018-36501-1 |
work_keys_str_mv | AT kimjeongrye comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis AT yoonheemang comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis AT jungahyoung comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis AT choyoungah comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis AT seojongjin comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis AT leejinseong comparisonofwholebodymribonescanandradiographicskeletalsurveyforlesiondetectionandriskstratificationoflangerhanscellhistiocytosis |