Cargando…

Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

Trophoblast oxidative phosphorylation provides energy for active transport and protein synthesis, which are critical placental functions influencing fetal growth and long-term health. The molecular mechanisms regulating trophoblast mitochondrial oxidative phosphorylation are largely unknown. We hypo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosario, Fredrick J., Gupta, Madhulika B., Myatt, Leslie, Powell, Theresa L., Glenn, Jeremy P., Cox, Laura, Jansson, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343003/ https://www.ncbi.nlm.nih.gov/pubmed/30670706 http://dx.doi.org/10.1038/s41598-018-36265-8

Ejemplares similares

Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome
por: Rosario, Fredrick J., et al.
Publicado: (2021)

Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
por: Rosario, Fredrick J., et al.
Publicado: (2016)

Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability
por: Rosario, Fredrick J., et al.
Publicado: (2023)

mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells
por: Rosario, Fredrick J., et al.
Publicado: (2020)

Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells
por: Nandi, Pinki, et al.
Publicado: (2021)

Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture
por: Rosario, Fredrick J., et al.
Publicado: (2021)

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR
por: Chen, Yi-Yung, et al.
Publicado: (2015)

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary
por: Hinkle, Jason S., et al.
Publicado: (2022)

Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
por: Henry, Fredrick E., et al.
Publicado: (2017)

Mechanistic Target of Rapamycin Pathway in Epileptic Disorders
por: Kim, Jang Keun, et al.
Publicado: (2019)

The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo
por: Shrivastav, Anuraag, et al.
Publicado: (2014)

Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells
por: Jones, Helen N., et al.
Publicado: (2010)

Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
por: Kelly, Amy, et al.
Publicado: (2023)

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth
por: Rosario, Fredrick J, et al.
Publicado: (2015)

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
por: Murray, James T., et al.
Publicado: (2018)

Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
por: Rosario, Fredrick J., et al.
Publicado: (2017)

TNF-α stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling
por: Aye, Irving L M H, et al.
Publicado: (2015)

Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas
por: Bi, Chengfeng, et al.
Publicado: (2017)

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters
por: Rosario, Fredrick J., et al.
Publicado: (2011)

Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine
por: Kitada, Munehiro, et al.
Publicado: (2020)

Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics
por: Bhaoighill, Muireann Ní, et al.
Publicado: (2019)

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
por: Querfurth, Henry, et al.
Publicado: (2021)

Regulation of Human Trophoblast GLUT3 Glucose Transporter by Mammalian Target of Rapamycin Signaling
por: Xu, Jie, et al.
Publicado: (2015)

Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation
por: Salmond, Robert J., et al.
Publicado: (2015)

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
por: Civiletto, Gabriele, et al.
Publicado: (2018)

The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment
por: Maiese, Kenneth
Publicado: (2020)

Mechanistic target of rapamycin signaling in human nervous system development and disease
por: Girodengo, Marie, et al.
Publicado: (2022)

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth
por: Zhu, Yi, et al.
Publicado: (2013)

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses
por: Soliman, Ghada A.
Publicado: (2013)

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
por: Norwitz, Nicholas G., et al.
Publicado: (2020)

Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
por: Ding, Yonghe, et al.
Publicado: (2019)

Mechanistic target of rapamycin kinase (Mtor) is required for spermatogonial proliferation and differentiation in mice
por: Cao, Jun, et al.
Publicado: (2019)

Mechanistic Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Potential, Limitations, and Perspectives
por: Faes, Seraina, et al.
Publicado: (2021)

Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells
por: Kim, Sung Eun, et al.
Publicado: (2021)

Genetic and Environmental Contributions to Autism Spectrum Disorder Through Mechanistic Target of Rapamycin
por: Sato, Atsushi, et al.
Publicado: (2021)

Enhanced activation of mechanistic target of rapamycin complex 1 signaling in eruptive xanthomas
por: Huang, Yan, et al.
Publicado: (2023)

The biogenesis and regulation of the plant oxidative phosphorylation system
por: Ghifari, Abi S, et al.
Publicado: (2023)

Modulation of nonsense mediated decay by rapamycin
por: Martinez-Nunez, Rocio T., et al.
Publicado: (2017)

Convergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-treated Yeast Cells
por: Iesmantavicius, Vytautas, et al.
Publicado: (2014)

Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats
por: Liu, Shangjing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3oq0gdfm6h029aljil111peebn