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Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment

HIV-1 protease autoprocessing liberates the free mature protease from its Gag-Pol polyprotein precursor through a series of highly regulated autoproteolysis reactions. Herein, we report the development and validation (Z’ ≥ 0.50) of a cell-based functional assay for high-throughput screening (HTS) of...

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Detalles Bibliográficos
Autores principales:	Huang, Liangqun, Li, Linfeng, Tien, ChihFeng, LaBarbera, Daniel V., Chen, Chaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343032/ https://www.ncbi.nlm.nih.gov/pubmed/30670786 http://dx.doi.org/10.1038/s41598-018-36730-4

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