High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)

In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal cri...

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Detalles Bibliográficos
Autores principales: Cheng, Zhe A., Alba‐Perez, Andres, Gonzalez‐Garcia, Cristina, Donnelly, Hannah, Llopis‐Hernandez, Virginia, Jayawarna, Vineetha, Childs, Peter, Shields, David W., Cantini, Marco, Ruiz‐Cantu, Laura, Reid, Andrew, Windmill, James F. C., Addison, Elena S., Corr, Sandra, Marshall, William G., Dalby, Matthew J., Salmeron‐Sanchez, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343087/
http://dx.doi.org/10.1002/advs.201970009
Descripción
Sumario:In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. [Image: see text]

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