Cargando…
High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019)
In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal cri...
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343087/ http://dx.doi.org/10.1002/advs.201970009 |
| _version_ | 1783389218286862336 |
|---|---|
| author | Cheng, Zhe A. Alba‐Perez, Andres Gonzalez‐Garcia, Cristina Donnelly, Hannah Llopis‐Hernandez, Virginia Jayawarna, Vineetha Childs, Peter Shields, David W. Cantini, Marco Ruiz‐Cantu, Laura Reid, Andrew Windmill, James F. C. Addison, Elena S. Corr, Sandra Marshall, William G. Dalby, Matthew J. Salmeron‐Sanchez, Manuel |
| author_facet | Cheng, Zhe A. Alba‐Perez, Andres Gonzalez‐Garcia, Cristina Donnelly, Hannah Llopis‐Hernandez, Virginia Jayawarna, Vineetha Childs, Peter Shields, David W. Cantini, Marco Ruiz‐Cantu, Laura Reid, Andrew Windmill, James F. C. Addison, Elena S. Corr, Sandra Marshall, William G. Dalby, Matthew J. Salmeron‐Sanchez, Manuel |
| author_sort | Cheng, Zhe A. |
| collection | PubMed |
| description | In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. [Image: see text] |
| format | Online Article Text |
| id | pubmed-6343087 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63430872019-01-28 High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) Cheng, Zhe A. Alba‐Perez, Andres Gonzalez‐Garcia, Cristina Donnelly, Hannah Llopis‐Hernandez, Virginia Jayawarna, Vineetha Childs, Peter Shields, David W. Cantini, Marco Ruiz‐Cantu, Laura Reid, Andrew Windmill, James F. C. Addison, Elena S. Corr, Sandra Marshall, William G. Dalby, Matthew J. Salmeron‐Sanchez, Manuel Adv Sci (Weinh) Inside Front Cover In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient. [Image: see text] John Wiley and Sons Inc. 2019-01-22 /pmc/articles/PMC6343087/ http://dx.doi.org/10.1002/advs.201970009 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Front Cover Cheng, Zhe A. Alba‐Perez, Andres Gonzalez‐Garcia, Cristina Donnelly, Hannah Llopis‐Hernandez, Virginia Jayawarna, Vineetha Childs, Peter Shields, David W. Cantini, Marco Ruiz‐Cantu, Laura Reid, Andrew Windmill, James F. C. Addison, Elena S. Corr, Sandra Marshall, William G. Dalby, Matthew J. Salmeron‐Sanchez, Manuel High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title | High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title_full | High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title_fullStr | High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title_full_unstemmed | High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title_short | High Efficiency BMP‐2 Coatings: Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects (Adv. Sci. 2/2019) |
| title_sort | high efficiency bmp‐2 coatings: nanoscale coatings for ultralow dose bmp‐2‐driven regeneration of critical‐sized bone defects (adv. sci. 2/2019) |
| topic | Inside Front Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343087/ http://dx.doi.org/10.1002/advs.201970009 |
| work_keys_str_mv | AT chengzhea highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT albaperezandres highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT gonzalezgarciacristina highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT donnellyhannah highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT llopishernandezvirginia highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT jayawarnavineetha highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT childspeter highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT shieldsdavidw highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT cantinimarco highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT ruizcantulaura highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT reidandrew highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT windmilljamesfc highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT addisonelenas highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT corrsandra highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT marshallwilliamg highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT dalbymatthewj highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 AT salmeronsanchezmanuel highefficiencybmp2coatingsnanoscalecoatingsforultralowdosebmp2drivenregenerationofcriticalsizedbonedefectsadvsci22019 |