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Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology

The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especi...

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Autores principales: Liao, Qiu-Shi, Du, Qian, Lou, Jun, Xu, Jing-Yu, Xie, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343099/
https://www.ncbi.nlm.nih.gov/pubmed/30686898
http://dx.doi.org/10.3748/wjg.v25.i3.287
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author Liao, Qiu-Shi
Du, Qian
Lou, Jun
Xu, Jing-Yu
Xie, Rui
author_facet Liao, Qiu-Shi
Du, Qian
Lou, Jun
Xu, Jing-Yu
Xie, Rui
author_sort Liao, Qiu-Shi
collection PubMed
description The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.
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spelling pubmed-63430992019-01-26 Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology Liao, Qiu-Shi Du, Qian Lou, Jun Xu, Jing-Yu Xie, Rui World J Gastroenterol Review The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments. Baishideng Publishing Group Inc 2019-01-21 2019-01-21 /pmc/articles/PMC6343099/ /pubmed/30686898 http://dx.doi.org/10.3748/wjg.v25.i3.287 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Liao, Qiu-Shi
Du, Qian
Lou, Jun
Xu, Jing-Yu
Xie, Rui
Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title_full Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title_fullStr Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title_full_unstemmed Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title_short Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
title_sort roles of na(+)/ca(2+) exchanger 1 in digestive system physiology and pathophysiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343099/
https://www.ncbi.nlm.nih.gov/pubmed/30686898
http://dx.doi.org/10.3748/wjg.v25.i3.287
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