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Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology
The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343099/ https://www.ncbi.nlm.nih.gov/pubmed/30686898 http://dx.doi.org/10.3748/wjg.v25.i3.287 |
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author | Liao, Qiu-Shi Du, Qian Lou, Jun Xu, Jing-Yu Xie, Rui |
author_facet | Liao, Qiu-Shi Du, Qian Lou, Jun Xu, Jing-Yu Xie, Rui |
author_sort | Liao, Qiu-Shi |
collection | PubMed |
description | The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments. |
format | Online Article Text |
id | pubmed-6343099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-63430992019-01-26 Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology Liao, Qiu-Shi Du, Qian Lou, Jun Xu, Jing-Yu Xie, Rui World J Gastroenterol Review The Na(+)/Ca(2+) exchanger (NCX) protein family is a part of the cation/Ca(2+) exchanger superfamily and participates in the regulation of cellular Ca(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments. Baishideng Publishing Group Inc 2019-01-21 2019-01-21 /pmc/articles/PMC6343099/ /pubmed/30686898 http://dx.doi.org/10.3748/wjg.v25.i3.287 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Liao, Qiu-Shi Du, Qian Lou, Jun Xu, Jing-Yu Xie, Rui Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title | Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title_full | Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title_fullStr | Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title_full_unstemmed | Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title_short | Roles of Na(+)/Ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
title_sort | roles of na(+)/ca(2+) exchanger 1 in digestive system physiology and pathophysiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343099/ https://www.ncbi.nlm.nih.gov/pubmed/30686898 http://dx.doi.org/10.3748/wjg.v25.i3.287 |
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