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Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression
[Image: see text] Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of th...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343109/ https://www.ncbi.nlm.nih.gov/pubmed/30620608 http://dx.doi.org/10.1021/acs.orglett.8b03769 |
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| author | El-Elimat, Tamam Raja, Huzefa A. Ayers, Sloan Kurina, Steven J. Burdette, Joanna E. Mattes, Zachary Sabatelle, Robert Bacon, Jeffrey W. Colby, Aaron H. Grinstaff, Mark W. Pearce, Cedric J. Oberlies, Nicholas H. |
| author_facet | El-Elimat, Tamam Raja, Huzefa A. Ayers, Sloan Kurina, Steven J. Burdette, Joanna E. Mattes, Zachary Sabatelle, Robert Bacon, Jeffrey W. Colby, Aaron H. Grinstaff, Mark W. Pearce, Cedric J. Oberlies, Nicholas H. |
| author_sort | El-Elimat, Tamam |
| collection | PubMed |
| description | [Image: see text] Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC(50) values while not inducing mitochondrial toxicity at 12.5 μM. |
| format | Online Article Text |
| id | pubmed-6343109 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | American
Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63431092019-01-28 Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression El-Elimat, Tamam Raja, Huzefa A. Ayers, Sloan Kurina, Steven J. Burdette, Joanna E. Mattes, Zachary Sabatelle, Robert Bacon, Jeffrey W. Colby, Aaron H. Grinstaff, Mark W. Pearce, Cedric J. Oberlies, Nicholas H. Org Lett [Image: see text] Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC(50) values while not inducing mitochondrial toxicity at 12.5 μM. American Chemical Society 2019-01-08 2019-01-18 /pmc/articles/PMC6343109/ /pubmed/30620608 http://dx.doi.org/10.1021/acs.orglett.8b03769 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | El-Elimat, Tamam Raja, Huzefa A. Ayers, Sloan Kurina, Steven J. Burdette, Joanna E. Mattes, Zachary Sabatelle, Robert Bacon, Jeffrey W. Colby, Aaron H. Grinstaff, Mark W. Pearce, Cedric J. Oberlies, Nicholas H. Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression |
| title | Meroterpenoids from Neosetophoma sp.:
A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific
Expression |
| title_full | Meroterpenoids from Neosetophoma sp.:
A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific
Expression |
| title_fullStr | Meroterpenoids from Neosetophoma sp.:
A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific
Expression |
| title_full_unstemmed | Meroterpenoids from Neosetophoma sp.:
A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific
Expression |
| title_short | Meroterpenoids from Neosetophoma sp.:
A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific
Expression |
| title_sort | meroterpenoids from neosetophoma sp.:
a dioxa[4.3.3]propellane ring system, potent cytotoxicity, and prolific
expression |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343109/ https://www.ncbi.nlm.nih.gov/pubmed/30620608 http://dx.doi.org/10.1021/acs.orglett.8b03769 |
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