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A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester

Little is known about the clinical value of the Hadlock and INTERGROWTH-21(st) EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and...

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Autores principales: Zhu, Chen, Ren, Yun-Yun, Wu, Jiang-Nan, Zhou, Qiong-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343179/
https://www.ncbi.nlm.nih.gov/pubmed/30729130
http://dx.doi.org/10.1155/2019/7698038
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author Zhu, Chen
Ren, Yun-Yun
Wu, Jiang-Nan
Zhou, Qiong-Jie
author_facet Zhu, Chen
Ren, Yun-Yun
Wu, Jiang-Nan
Zhou, Qiong-Jie
author_sort Zhu, Chen
collection PubMed
description Little is known about the clinical value of the Hadlock and INTERGROWTH-21(st) EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and compare predictions of APOs between Hadlock and INTERGROWTH-21(st) EFW standards. A prospective cohort of 690 singleton pregnancies with ultrasonography performed in the third trimester between March 2015 and March 2016 in China was conducted. EFW and the corresponding EFWc were measured using the Hadlock and INTERGROWTH-21(st) standards, respectively. Cox proportional hazard models were used to assess the relationship between low EFWc (i.e., <5 percentile, P5) and the risk of APOs. Compared with fetuses with ≥P5 of the EFWc, fetuses with <P5 of the EFWc were much more likely to have an APO, with adjusted hazard ratios of 35.0 (95% confidence interval, 13.9-88.5) and 17.5 (7.7-39.6) for the Hadlock and INTERGROWTH standards, respectively. The Hadlock-EFWc had a higher predictive accuracy for APOs than the INTERGROWTH-EFWc, with area under the receiver operating characteristic curve of 0.94 (0.92-0.95) and 0.90 (0.87-0.92), respectively (P=0.007). The cutoff value for the INTERGROWTH-EFWc was percentile 11.61 with a sensitivity and specificity of 87.9% and 80.5%, respectively. For the Hadlock-EFWc, the corresponding sensitivity and specificity were 93.9% and 81.2%, with a cutoff value of percentile 8.65. Fetuses with low EFWc (i.e., <P5) were associated with an increased risk of APOs. APOs were more accurately predicted when EFWc was measured by the Hadlock standard than by the INTERGROWTH-21(st) standard.
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spelling pubmed-63431792019-02-06 A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester Zhu, Chen Ren, Yun-Yun Wu, Jiang-Nan Zhou, Qiong-Jie Biomed Res Int Research Article Little is known about the clinical value of the Hadlock and INTERGROWTH-21(st) EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and compare predictions of APOs between Hadlock and INTERGROWTH-21(st) EFW standards. A prospective cohort of 690 singleton pregnancies with ultrasonography performed in the third trimester between March 2015 and March 2016 in China was conducted. EFW and the corresponding EFWc were measured using the Hadlock and INTERGROWTH-21(st) standards, respectively. Cox proportional hazard models were used to assess the relationship between low EFWc (i.e., <5 percentile, P5) and the risk of APOs. Compared with fetuses with ≥P5 of the EFWc, fetuses with <P5 of the EFWc were much more likely to have an APO, with adjusted hazard ratios of 35.0 (95% confidence interval, 13.9-88.5) and 17.5 (7.7-39.6) for the Hadlock and INTERGROWTH standards, respectively. The Hadlock-EFWc had a higher predictive accuracy for APOs than the INTERGROWTH-EFWc, with area under the receiver operating characteristic curve of 0.94 (0.92-0.95) and 0.90 (0.87-0.92), respectively (P=0.007). The cutoff value for the INTERGROWTH-EFWc was percentile 11.61 with a sensitivity and specificity of 87.9% and 80.5%, respectively. For the Hadlock-EFWc, the corresponding sensitivity and specificity were 93.9% and 81.2%, with a cutoff value of percentile 8.65. Fetuses with low EFWc (i.e., <P5) were associated with an increased risk of APOs. APOs were more accurately predicted when EFWc was measured by the Hadlock standard than by the INTERGROWTH-21(st) standard. Hindawi 2019-01-09 /pmc/articles/PMC6343179/ /pubmed/30729130 http://dx.doi.org/10.1155/2019/7698038 Text en Copyright © 2019 Chen Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Chen
Ren, Yun-Yun
Wu, Jiang-Nan
Zhou, Qiong-Jie
A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title_full A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title_fullStr A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title_full_unstemmed A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title_short A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21(st) Standards at the Third Trimester
title_sort comparison of prediction of adverse perinatal outcomes between hadlock and intergrowth-21(st) standards at the third trimester
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343179/
https://www.ncbi.nlm.nih.gov/pubmed/30729130
http://dx.doi.org/10.1155/2019/7698038
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