Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

BACKGROUND: Identifying effective strategies to prevent memory loss in AD has eluded researchers to date, and likely reflects insufficient understanding of early pathogenic mechanisms directly affecting memory encoding. As synaptic loss best correlates with memory loss in AD, refocusing efforts to i...

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Detalles Bibliográficos
Autores principales: Chakroborty, Shreaya, Hill, Evan S., Christian, Daniel T., Helfrich, Rosalind, Riley, Shannon, Schneider, Corinne, Kapecki, Nicolas, Mustaly-Kalimi, Sarah, Seiler, Figen A., Peterson, Daniel A., West, Anthony R., Vertel, Barbara M., Frost, William N., Stutzmann, Grace E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343260/
https://www.ncbi.nlm.nih.gov/pubmed/30670054
http://dx.doi.org/10.1186/s13024-019-0307-7

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