AFM Imaging Reveals Multiple Conformational States of ADAMTS13

BACKGROUND: ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Deficiency of ADAMTS13 caused by either genetic mutations or by inhibitory autoantib...

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Detalles Bibliográficos
Autores principales: Yu, Shanshan, Liu, Wang, Fang, Jinhua, Shi, Xiaozhong, Wu, Jianhua, Fang, Ying, Lin, Jiangguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343300/
https://www.ncbi.nlm.nih.gov/pubmed/30679946
http://dx.doi.org/10.1186/s13036-018-0102-y

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