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Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

BACKGROUND: Elevated aerobic glycolysis rate is a biochemical alteration associated with malignant transformation and cancer progression. This metabolic shift unavoidably generates methylglyoxal (MG), a potent inducer of dicarbonyl stress through the formation of advanced glycation end products (AGE...

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Detalles Bibliográficos
Autores principales:	Nokin, Marie-Julie, Bellier, Justine, Durieux, Florence, Peulen, Olivier, Rademaker, Gilles, Gabriel, Maude, Monseur, Christine, Charloteaux, Benoit, Verbeke, Lieven, van Laere, Steven, Roncarati, Patrick, Herfs, Michael, Lambert, Charles, Scheijen, Jean, Schalkwijk, Casper, Colige, Alain, Caers, Jo, Delvenne, Philippe, Turtoi, Andrei, Castronovo, Vincent, Bellahcène, Akeila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343302/ https://www.ncbi.nlm.nih.gov/pubmed/30674353 http://dx.doi.org/10.1186/s13058-018-1095-7

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