Connexin-43 Enhances the Redesigned Cytosine Deaminase Activity for Suicide Gene Therapy in Human Breast Cancer Cells

BACKGROUND: Escherichia coli cytosine deaminase (CD) converts 5-fluorocytosine (5-FC), a prodrug, into 5-fluorouracil (5-FU), a chemotherapeutic drug. However, the poor binding affinity of CD towards 5-FC as compared to the natural substrate cytosine, limits its application towards a successful suic...

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Detalles Bibliográficos
Autores principales: Raza, Asif, Ghosh, Siddhartha Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343436/
https://www.ncbi.nlm.nih.gov/pubmed/30733628
http://dx.doi.org/10.1177/1178626418818182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343436/
https://www.ncbi.nlm.nih.gov/pubmed/30733628
http://dx.doi.org/10.1177/1178626418818182

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