MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. How...

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Detalles Bibliográficos
Autores principales: Zhang, Fan, Zakaria, Siti Mariam, Högqvist Tabor, Vedrana, Singh, Madhurendra, Tronnersjö, Susanna, Goodwin, Jacob, Selivanova, Galina, Bartek, Jiri, Castell, Alina, Larsson, Lars-Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343716/
https://www.ncbi.nlm.nih.gov/pubmed/30526305
http://dx.doi.org/10.1080/15384101.2018.1553339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343716/
https://www.ncbi.nlm.nih.gov/pubmed/30526305
http://dx.doi.org/10.1080/15384101.2018.1553339

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