Rapamycin, proliferation and geroconversion to senescence

Rapamycin inhibits cell proliferation, yet preserves (re)-proliferative potential (RPP). RPP is a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from quiescence to senescence (geroconversion). By suppressing geroconversion, rapamycin preserves RPP. Geroconversio...

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Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343718/
https://www.ncbi.nlm.nih.gov/pubmed/30541374
http://dx.doi.org/10.1080/15384101.2018.1554781
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description Rapamycin inhibits cell proliferation, yet preserves (re)-proliferative potential (RPP). RPP is a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from quiescence to senescence (geroconversion). By suppressing geroconversion, rapamycin preserves RPP. Geroconversion is characterized by proliferation-like levels of phospho-S6K/S6/4E-BP1 in nonproliferating cells arrested by p16 and/or p21. mTOR-driven geroconversion is associated with cellular hyperfunction, which in turn leads to organismal aging manifested by age-related diseases.
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spelling pubmed-63437182019-02-01 Rapamycin, proliferation and geroconversion to senescence Blagosklonny, Mikhail V. Cell Cycle Perspectives Rapamycin inhibits cell proliferation, yet preserves (re)-proliferative potential (RPP). RPP is a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from quiescence to senescence (geroconversion). By suppressing geroconversion, rapamycin preserves RPP. Geroconversion is characterized by proliferation-like levels of phospho-S6K/S6/4E-BP1 in nonproliferating cells arrested by p16 and/or p21. mTOR-driven geroconversion is associated with cellular hyperfunction, which in turn leads to organismal aging manifested by age-related diseases. Taylor & Francis 2018-12-12 /pmc/articles/PMC6343718/ /pubmed/30541374 http://dx.doi.org/10.1080/15384101.2018.1554781 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Perspectives
Blagosklonny, Mikhail V.
Rapamycin, proliferation and geroconversion to senescence
title Rapamycin, proliferation and geroconversion to senescence
title_full Rapamycin, proliferation and geroconversion to senescence
title_fullStr Rapamycin, proliferation and geroconversion to senescence
title_full_unstemmed Rapamycin, proliferation and geroconversion to senescence
title_short Rapamycin, proliferation and geroconversion to senescence
title_sort rapamycin, proliferation and geroconversion to senescence
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343718/
https://www.ncbi.nlm.nih.gov/pubmed/30541374
http://dx.doi.org/10.1080/15384101.2018.1554781
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