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Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults

[PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percen...

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Autores principales: Lee, Inhwan, Cho, Jinkyung, Park, Jinkook, Kang, Hyunsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 한국운동영양학회 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343763/
https://www.ncbi.nlm.nih.gov/pubmed/30661332
http://dx.doi.org/10.20463/jenb.2018.0031
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author Lee, Inhwan
Cho, Jinkyung
Park, Jinkook
Kang, Hyunsik
author_facet Lee, Inhwan
Cho, Jinkyung
Park, Jinkook
Kang, Hyunsik
author_sort Lee, Inhwan
collection PubMed
description [PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percent body fat, body mass index (BMI), waist circumference (WC), was determined using body composition analyzer. HGS was assessed using a dynamometer, and NAFLD was diagnosed by the simple NAFLD score (SNS), hepatic steatosis index (HSI), NAFLD fibrosis score (NFS), and fibrosis 4 calculator (FIB-4). Based on relative HGS, subjects were classified as High HGS, Mid HGS, and Low HGS group. Based on SNS, HSI, NFS and FIB-4 score, subjects were classified as High risk and Low risk group. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence interval (CI) of HGS levels for having steatosis and fibrosis. [RESULTS]: There were linear decreases in NAFLD index such as SNS (P<.001), HSI (P<.001), NFS (P=.001), and FIB-4 (P=.041) across incremental HGS levels. Compared to the High HGS group (reference), the Low HGS group had significantly higher ORs of having SNS (OR=4.583, 95% CI=2.608-8.054, P<.001), HSI (OR=11.697, 95% CI=5.261-26.005, P<.001), and NFS (OR=1.709, 95% CI=1.005-2.907, P=.048). [CONCLUSION]: The current findings suggest that a lifestyle intervention consisting of a normal weight and physical fitness should be promoted as a preventive means against NAFLD associated with HGS.
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spelling pubmed-63437632019-01-30 Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults Lee, Inhwan Cho, Jinkyung Park, Jinkook Kang, Hyunsik J Exerc Nutrition Biochem Original Articles [PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percent body fat, body mass index (BMI), waist circumference (WC), was determined using body composition analyzer. HGS was assessed using a dynamometer, and NAFLD was diagnosed by the simple NAFLD score (SNS), hepatic steatosis index (HSI), NAFLD fibrosis score (NFS), and fibrosis 4 calculator (FIB-4). Based on relative HGS, subjects were classified as High HGS, Mid HGS, and Low HGS group. Based on SNS, HSI, NFS and FIB-4 score, subjects were classified as High risk and Low risk group. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence interval (CI) of HGS levels for having steatosis and fibrosis. [RESULTS]: There were linear decreases in NAFLD index such as SNS (P<.001), HSI (P<.001), NFS (P=.001), and FIB-4 (P=.041) across incremental HGS levels. Compared to the High HGS group (reference), the Low HGS group had significantly higher ORs of having SNS (OR=4.583, 95% CI=2.608-8.054, P<.001), HSI (OR=11.697, 95% CI=5.261-26.005, P<.001), and NFS (OR=1.709, 95% CI=1.005-2.907, P=.048). [CONCLUSION]: The current findings suggest that a lifestyle intervention consisting of a normal weight and physical fitness should be promoted as a preventive means against NAFLD associated with HGS. 한국운동영양학회 2018-12-31 /pmc/articles/PMC6343763/ /pubmed/30661332 http://dx.doi.org/10.20463/jenb.2018.0031 Text en ©2018 The Korean Society for Exercise Nutrition ©2018 Inhwan Lee et al; License Journal of Exercise Nutrition and Biochemistry. This is an open access article distributed under the terms of the creative commons attribution license (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the orginal work is properly cited.
spellingShingle Original Articles
Lee, Inhwan
Cho, Jinkyung
Park, Jinkook
Kang, Hyunsik
Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title_full Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title_fullStr Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title_full_unstemmed Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title_short Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
title_sort association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343763/
https://www.ncbi.nlm.nih.gov/pubmed/30661332
http://dx.doi.org/10.20463/jenb.2018.0031
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