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Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults
[PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
한국운동영양학회
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343763/ https://www.ncbi.nlm.nih.gov/pubmed/30661332 http://dx.doi.org/10.20463/jenb.2018.0031 |
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author | Lee, Inhwan Cho, Jinkyung Park, Jinkook Kang, Hyunsik |
author_facet | Lee, Inhwan Cho, Jinkyung Park, Jinkook Kang, Hyunsik |
author_sort | Lee, Inhwan |
collection | PubMed |
description | [PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percent body fat, body mass index (BMI), waist circumference (WC), was determined using body composition analyzer. HGS was assessed using a dynamometer, and NAFLD was diagnosed by the simple NAFLD score (SNS), hepatic steatosis index (HSI), NAFLD fibrosis score (NFS), and fibrosis 4 calculator (FIB-4). Based on relative HGS, subjects were classified as High HGS, Mid HGS, and Low HGS group. Based on SNS, HSI, NFS and FIB-4 score, subjects were classified as High risk and Low risk group. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence interval (CI) of HGS levels for having steatosis and fibrosis. [RESULTS]: There were linear decreases in NAFLD index such as SNS (P<.001), HSI (P<.001), NFS (P=.001), and FIB-4 (P=.041) across incremental HGS levels. Compared to the High HGS group (reference), the Low HGS group had significantly higher ORs of having SNS (OR=4.583, 95% CI=2.608-8.054, P<.001), HSI (OR=11.697, 95% CI=5.261-26.005, P<.001), and NFS (OR=1.709, 95% CI=1.005-2.907, P=.048). [CONCLUSION]: The current findings suggest that a lifestyle intervention consisting of a normal weight and physical fitness should be promoted as a preventive means against NAFLD associated with HGS. |
format | Online Article Text |
id | pubmed-6343763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | 한국운동영양학회 |
record_format | MEDLINE/PubMed |
spelling | pubmed-63437632019-01-30 Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults Lee, Inhwan Cho, Jinkyung Park, Jinkook Kang, Hyunsik J Exerc Nutrition Biochem Original Articles [PURPOSE]: This study examined the association of hand-grip strength (HGS) and non-alcoholic fatty liver disease (NAFLD) index in older adults. [METHODS]: This was a cross-sectional study involving 538 older adults with mean age of 74.3±6.4 years. Body composition parameters including height, percent body fat, body mass index (BMI), waist circumference (WC), was determined using body composition analyzer. HGS was assessed using a dynamometer, and NAFLD was diagnosed by the simple NAFLD score (SNS), hepatic steatosis index (HSI), NAFLD fibrosis score (NFS), and fibrosis 4 calculator (FIB-4). Based on relative HGS, subjects were classified as High HGS, Mid HGS, and Low HGS group. Based on SNS, HSI, NFS and FIB-4 score, subjects were classified as High risk and Low risk group. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence interval (CI) of HGS levels for having steatosis and fibrosis. [RESULTS]: There were linear decreases in NAFLD index such as SNS (P<.001), HSI (P<.001), NFS (P=.001), and FIB-4 (P=.041) across incremental HGS levels. Compared to the High HGS group (reference), the Low HGS group had significantly higher ORs of having SNS (OR=4.583, 95% CI=2.608-8.054, P<.001), HSI (OR=11.697, 95% CI=5.261-26.005, P<.001), and NFS (OR=1.709, 95% CI=1.005-2.907, P=.048). [CONCLUSION]: The current findings suggest that a lifestyle intervention consisting of a normal weight and physical fitness should be promoted as a preventive means against NAFLD associated with HGS. 한국운동영양학회 2018-12-31 /pmc/articles/PMC6343763/ /pubmed/30661332 http://dx.doi.org/10.20463/jenb.2018.0031 Text en ©2018 The Korean Society for Exercise Nutrition ©2018 Inhwan Lee et al; License Journal of Exercise Nutrition and Biochemistry. This is an open access article distributed under the terms of the creative commons attribution license (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the orginal work is properly cited. |
spellingShingle | Original Articles Lee, Inhwan Cho, Jinkyung Park, Jinkook Kang, Hyunsik Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title | Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title_full | Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title_fullStr | Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title_full_unstemmed | Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title_short | Association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
title_sort | association of hand-grip strength and non-alcoholic fatty liver disease index in older adults |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343763/ https://www.ncbi.nlm.nih.gov/pubmed/30661332 http://dx.doi.org/10.20463/jenb.2018.0031 |
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