Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate

Circulating T-cells that have passed thymic selection generally bear T-cell receptors (TCRs) with sub-optimal affinity for cancer-associated antigens, resulting in a limited ability to detect and eliminate tumor cells. Engineering TCRs to increase their affinity for cancer targets is a promising str...

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Detalles Bibliográficos
Autores principales: Border, Ellen C., Sanderson, Joseph P., Weissensteiner, Thomas, Gerry, Andrew B., Pumphrey, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343776/
https://www.ncbi.nlm.nih.gov/pubmed/30713784
http://dx.doi.org/10.1080/2162402X.2018.1532759

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