High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

As an immune evasion strategy, MICA and MICB, the major histocompatibility complex class I homologs, are proteolytically cleaved from the surface of cancer cells leading to impairment of CD8 + T cell- and natural killer cell-mediated immune responses. Antibodies that inhibit MICA/B shedding from tum...

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Detalles Bibliográficos
Autores principales: Lombana, T. Noelle, Matsumoto, Marissa L., Bevers III, Jack, Berkley, Amy M., Toy, Evangeline, Cook, Ryan, Gan, Yutian, Du, Changchun, Liu, Peter, Schnier, Paul, Sandoval, Wendy, Ye, Zhengmao, Schartner, Jill M., Kim, Jeong, Spiess, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343778/
https://www.ncbi.nlm.nih.gov/pubmed/30307368
http://dx.doi.org/10.1080/19420862.2018.1532767

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