Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry

Charge variant analysis is a widely used tool to monitor changes in product quality during the manufacturing process of monoclonal antibodies (mAbs). Although it is a powerful technique for revealing mAb heterogeneity, an unexpected outcome, for example the appearance of previously undetected isofor...

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Detalles Bibliográficos
Autores principales: Füssl, Florian, Trappe, Anne, Cook, Ken, Scheffler, Kai, Fitzgerald, Oliver, Bones, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343805/
https://www.ncbi.nlm.nih.gov/pubmed/30296204
http://dx.doi.org/10.1080/19420862.2018.1531664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343805/
https://www.ncbi.nlm.nih.gov/pubmed/30296204
http://dx.doi.org/10.1080/19420862.2018.1531664

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