Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successful infection. Using transcriptome sequencing, we f...

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Detalles Bibliográficos
Autores principales: Abdallah, Abdallah M., Weerdenburg, Eveline M., Guan, Qingtian, Ummels, Roy, Borggreve, Stephanie, Adroub, Sabir A., Malas, Tareq B., Naeem, Raeece, Zhang, Huoming, Otto, Thomas D., Bitter, Wilbert, Pain, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343904/
https://www.ncbi.nlm.nih.gov/pubmed/30673778
http://dx.doi.org/10.1371/journal.pone.0211003

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