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Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire

INTRODUCTION: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host’s immune response and susceptibility and thus impact on morbidity. There is little informati...

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Autores principales: Hürlimann, Eveline, Houngbedji, Clarisse A., Yapi, Richard B., N’Dri, Prisca B., Silué, Kigbafori D., Ouattara, Mamadou, Utzinger, Jürg, N’Goran, Eliézer K., Raso, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929/
https://www.ncbi.nlm.nih.gov/pubmed/30629580
http://dx.doi.org/10.1371/journal.pntd.0007086
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author Hürlimann, Eveline
Houngbedji, Clarisse A.
Yapi, Richard B.
N’Dri, Prisca B.
Silué, Kigbafori D.
Ouattara, Mamadou
Utzinger, Jürg
N’Goran, Eliézer K.
Raso, Giovanna
author_facet Hürlimann, Eveline
Houngbedji, Clarisse A.
Yapi, Richard B.
N’Dri, Prisca B.
Silué, Kigbafori D.
Ouattara, Mamadou
Utzinger, Jürg
N’Goran, Eliézer K.
Raso, Giovanna
author_sort Hürlimann, Eveline
collection PubMed
description INTRODUCTION: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host’s immune response and susceptibility and thus impact on morbidity. There is little information on the direction and magnitude of such interactions and results are conflicting. This study aimed at shedding new light on the potential interactions of Plasmodium and helminth co-infections on anemia and splenomegaly in different population groups in Côte d’Ivoire. METHODOLOGY: Parasitologic and clinical data were obtained from four cross-sectional community-based studies and a national school-based survey conducted between 2011 and 2013 in Côte d’Ivoire. Six scenarios of co-infection pairs defined as Plasmodium infection or high parasitemia, combined with one of three common helminth infections (i.e., Schistosoma mansoni, S. haematobium, and hookworm) served for analysis. Adjusted logistic regression models were built for each scenario and interaction measures on additive scale calculated according to Rothman et al., while an interaction term in the model served as multiplicative scale measure. PRINCIPAL FINDINGS: All identified significant interactions were of antagonistic nature but varied in magnitude and species combination. In study participants aged 5–18 years from community-based studies, Plasmodium-hookworm co-infection showed an antagonistic interaction on additive scale on splenomegaly, while Plasmodium-Schistosoma co-infection scenarios showed protective effects on multiplicative scale for anemia and splenomegaly in participants aged 5–16 years from a school-based study. CONCLUSIONS/SIGNIFICANCE: No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5–18 years nor in adults from the community-based studies. Future studies should unravel underlying mechanisms of the observed interactions, as this knowledge might help shaping control efforts against these diseases of poverty.
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spelling pubmed-63439292019-02-01 Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire Hürlimann, Eveline Houngbedji, Clarisse A. Yapi, Richard B. N’Dri, Prisca B. Silué, Kigbafori D. Ouattara, Mamadou Utzinger, Jürg N’Goran, Eliézer K. Raso, Giovanna PLoS Negl Trop Dis Research Article INTRODUCTION: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host’s immune response and susceptibility and thus impact on morbidity. There is little information on the direction and magnitude of such interactions and results are conflicting. This study aimed at shedding new light on the potential interactions of Plasmodium and helminth co-infections on anemia and splenomegaly in different population groups in Côte d’Ivoire. METHODOLOGY: Parasitologic and clinical data were obtained from four cross-sectional community-based studies and a national school-based survey conducted between 2011 and 2013 in Côte d’Ivoire. Six scenarios of co-infection pairs defined as Plasmodium infection or high parasitemia, combined with one of three common helminth infections (i.e., Schistosoma mansoni, S. haematobium, and hookworm) served for analysis. Adjusted logistic regression models were built for each scenario and interaction measures on additive scale calculated according to Rothman et al., while an interaction term in the model served as multiplicative scale measure. PRINCIPAL FINDINGS: All identified significant interactions were of antagonistic nature but varied in magnitude and species combination. In study participants aged 5–18 years from community-based studies, Plasmodium-hookworm co-infection showed an antagonistic interaction on additive scale on splenomegaly, while Plasmodium-Schistosoma co-infection scenarios showed protective effects on multiplicative scale for anemia and splenomegaly in participants aged 5–16 years from a school-based study. CONCLUSIONS/SIGNIFICANCE: No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5–18 years nor in adults from the community-based studies. Future studies should unravel underlying mechanisms of the observed interactions, as this knowledge might help shaping control efforts against these diseases of poverty. Public Library of Science 2019-01-10 /pmc/articles/PMC6343929/ /pubmed/30629580 http://dx.doi.org/10.1371/journal.pntd.0007086 Text en © 2019 Hürlimann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hürlimann, Eveline
Houngbedji, Clarisse A.
Yapi, Richard B.
N’Dri, Prisca B.
Silué, Kigbafori D.
Ouattara, Mamadou
Utzinger, Jürg
N’Goran, Eliézer K.
Raso, Giovanna
Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title_full Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title_fullStr Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title_full_unstemmed Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title_short Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire
title_sort antagonistic effects of plasmodium-helminth co-infections on malaria pathology in different population groups in côte d’ivoire
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929/
https://www.ncbi.nlm.nih.gov/pubmed/30629580
http://dx.doi.org/10.1371/journal.pntd.0007086
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