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Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review
BACKGROUND: The goal of this paper was to identify available biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: Case-control studies comparing the different concentrations of a series of molecules detected in serum and urine as matrices o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344011/ https://www.ncbi.nlm.nih.gov/pubmed/30595601 http://dx.doi.org/10.4317/medoral.22763 |
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author | Lorenzo-Pouso, Alejandro I. Pérez-Sayáns, Mario González-Palanca, Sergio Chamorro-Petronacci, Cintia Bagán, José García-García, Abel |
author_facet | Lorenzo-Pouso, Alejandro I. Pérez-Sayáns, Mario González-Palanca, Sergio Chamorro-Petronacci, Cintia Bagán, José García-García, Abel |
author_sort | Lorenzo-Pouso, Alejandro I. |
collection | PubMed |
description | BACKGROUND: The goal of this paper was to identify available biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: Case-control studies comparing the different concentrations of a series of molecules detected in serum and urine as matrices of BRONJ affected patients vs. non-affected were included. PRISMA guidelines for systematic reviews were used for the present paper. Two reviewers independently screened electronic databases (Medline, Web of science, and The Cochrane Library) and performed hand searches. Risk of bias assessment of selected studies was performed by the Newcastle-Ottawa Scale. This study is registered as PROSPERO CRD42017078149. RESULTS: From a total of 601 identified studies, 7 (4 articles with high methodological quality and 3 with medium) articles were included. They investigate 2623 patients, of whom 91 (3.47%) developed BRONJ. A total of 7 biomarkers were identified and classified into 3 groups: bone turnover, angiogenesis and endocrine markers. Conflicting results were found in relation to most biomarkers. CONCLUSIONS: The present review suggests that no useful markers are currently available to evaluate BRONJ risk. Nevertheless, the present paper indicates that a paradigm shift from bone turnover biomarkers to angiogenesis and endocrine markers could shed light on this search. Key words:Biphosphonate, jaw, osteonecrosis, osteoporosis. |
format | Online Article Text |
id | pubmed-6344011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63440112019-01-29 Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review Lorenzo-Pouso, Alejandro I. Pérez-Sayáns, Mario González-Palanca, Sergio Chamorro-Petronacci, Cintia Bagán, José García-García, Abel Med Oral Patol Oral Cir Bucal Review BACKGROUND: The goal of this paper was to identify available biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: Case-control studies comparing the different concentrations of a series of molecules detected in serum and urine as matrices of BRONJ affected patients vs. non-affected were included. PRISMA guidelines for systematic reviews were used for the present paper. Two reviewers independently screened electronic databases (Medline, Web of science, and The Cochrane Library) and performed hand searches. Risk of bias assessment of selected studies was performed by the Newcastle-Ottawa Scale. This study is registered as PROSPERO CRD42017078149. RESULTS: From a total of 601 identified studies, 7 (4 articles with high methodological quality and 3 with medium) articles were included. They investigate 2623 patients, of whom 91 (3.47%) developed BRONJ. A total of 7 biomarkers were identified and classified into 3 groups: bone turnover, angiogenesis and endocrine markers. Conflicting results were found in relation to most biomarkers. CONCLUSIONS: The present review suggests that no useful markers are currently available to evaluate BRONJ risk. Nevertheless, the present paper indicates that a paradigm shift from bone turnover biomarkers to angiogenesis and endocrine markers could shed light on this search. Key words:Biphosphonate, jaw, osteonecrosis, osteoporosis. Medicina Oral S.L. 2019-01 /pmc/articles/PMC6344011/ /pubmed/30595601 http://dx.doi.org/10.4317/medoral.22763 Text en Copyright: © 2019 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lorenzo-Pouso, Alejandro I. Pérez-Sayáns, Mario González-Palanca, Sergio Chamorro-Petronacci, Cintia Bagán, José García-García, Abel Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title | Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title_full | Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title_fullStr | Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title_full_unstemmed | Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title_short | Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review |
title_sort | biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344011/ https://www.ncbi.nlm.nih.gov/pubmed/30595601 http://dx.doi.org/10.4317/medoral.22763 |
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