Cargando…

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of metabolism, whose activation has been proposed to be therapeutically beneficial for the treatment of several metabolic diseases, including nonalcoholic fatty liver disease (NAFLD). NAFLD, characterized by excessive acc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344045/ https://www.ncbi.nlm.nih.gov/pubmed/30605676 http://dx.doi.org/10.1016/j.celrep.2018.12.036

Ejemplares similares

The circadian coordination of cell biology
por: Chaix, Amandine, et al.
Publicado: (2016)

Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice
por: Chaix, Amandine, et al.
Publicado: (2021)

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation
por: Van Nostrand, Jeanine L., et al.
Publicado: (2020)

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
por: Zarrinpar, Amir, et al.
Publicado: (2018)

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
por: Young, Nathan P., et al.
Publicado: (2016)

The influence of transcript assembly on the proteogenomics discovery of microproteins
por: Ma, Jiao, et al.
Publicado: (2018)

Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome
por: Machado, Ana Carolina Dantas, et al.
Publicado: (2022)

Serine restriction alters sphingolipid diversity to constrain tumor growth
por: Muthusamy, Thangaselvam, et al.
Publicado: (2020)

Reciprocal regulation between the molecular clock and kidney injury
por: Rey-Serra, Carlos, et al.
Publicado: (2023)

Accurate annotation of human protein-coding small open reading frames
por: Martinez, Thomas F., et al.
Publicado: (2019)

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy
por: Hung, Chien-Min, et al.
Publicado: (2021)

Parenteral Nutrition Associated Hepatic Steatosis and NAFLD Intersect at AMPK
por: Guthrie, Gregory
Publicado: (2022)

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender
por: Porcu, Cristiana, et al.
Publicado: (2018)

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
por: Choi, Seung H., et al.
Publicado: (2019)

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy
por: Handzlik, Michal K., et al.
Publicado: (2023)

Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
por: Tan, Tan, et al.
Publicado: (2023)

Mechanisms and consequences of hepatic regulation of mTORC1 by metformin
por: Howell, Jessica J, et al.
Publicado: (2014)

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene induced senescence
por: Sulli, Gabriele, et al.
Publicado: (2018)

Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models
por: Livelo, Christopher, et al.
Publicado: (2023)

The Untapped Potential of Circadian Timing as a Variable for Discoveries and Reproducibility
por: Panda, Satchidananda
Publicado: (2023)

Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway
por: Li, Rongrong, et al.
Publicado: (2022)

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
por: Xie, Liping, et al.
Publicado: (2022)

Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease
por: Miao, Zong, et al.
Publicado: (2021)

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
por: Esquejo, Ryan M., et al.
Publicado: (2018)

Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling
por: Lee, Geum-Hwa, et al.
Publicado: (2020)

Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways
por: Yong, Zhang, et al.
Publicado: (2021)

Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway
por: Liu, Yang, et al.
Publicado: (2022)

Comments on ‘Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1–AMPK–LKB1 complex’
por: Lu, Sijia, et al.
Publicado: (2023)

Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice
por: McClatchy, Daniel B., et al.
Publicado: (2015)

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels()
por: Dahlhoff, Christoph, et al.
Publicado: (2014)

Time for better time-restricted eating trials to lessen the burden of metabolic diseases
por: Taub, Pam R., et al.
Publicado: (2022)

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
por: Lee, Annie, et al.
Publicado: (2022)

Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling
por: Zou, Yunyi, et al.
Publicado: (2021)

Multi-objective swarm intelligence: theoretical advances and applications
por: Dehuri, Satchidananda, et al.
Publicado: (2015)

FlowMax: A Computational Tool for Maximum Likelihood Deconvolution of CFSE Time Courses
por: Shokhirev, Maxim Nikolaievich, et al.
Publicado: (2013)

Immunotherapy for NAFLD and NAFLD-related hepatocellular carcinoma
por: Jeong, Seogsong, et al.
Publicado: (2023)

Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition
por: Hirabayashi, Takumi, et al.
Publicado: (2021)

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
por: Li, Songtao, et al.
Publicado: (2020)

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells
por: Badur, Mehmet G., et al.
Publicado: (2018)

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells
por: Badur, Mehmet G., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0uo87mlcvo1dtmeqf7gkh14148