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No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors
INTRODUCTION: An increasing number of clinical studies involving a range of chronic pain conditions report widespread mechanical pressure pain hypersensitivity, which is commonly interpreted as resulting from central sensitization (CS). Secondary hyperalgesia (increased pinprick sensitivity surround...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344133/ https://www.ncbi.nlm.nih.gov/pubmed/30706036 http://dx.doi.org/10.1097/PR9.0000000000000691 |
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author | Cayrol, Timothée Pitance, Laurent Roussel, Nathalie Mouraux, André van den Broeke, Emanuel N. |
author_facet | Cayrol, Timothée Pitance, Laurent Roussel, Nathalie Mouraux, André van den Broeke, Emanuel N. |
author_sort | Cayrol, Timothée |
collection | PubMed |
description | INTRODUCTION: An increasing number of clinical studies involving a range of chronic pain conditions report widespread mechanical pressure pain hypersensitivity, which is commonly interpreted as resulting from central sensitization (CS). Secondary hyperalgesia (increased pinprick sensitivity surrounding the site of injury) is considered to be a manifestation of CS. However, it has not been rigorously tested whether CS induced by peripheral nociceptive input involves widespread mechanical pressure pain hypersensitivity. OBJECTIVES: The aim of this study was to assess whether high-frequency electrical stimulation (HFS), which induces a robust secondary hyperalgesia, also induces a widespread decrease of pressure pain thresholds (PPTs). METHODS: We measured PPTs bilaterally on the temples (temporalis muscles), on the legs (tibialis anterior muscles), and on the ventral forearm (flexor carpi radialis muscles) before, 20 minutes after, and 45 minutes after applying HFS on the ventral forearm of sixteen healthy young volunteers. To evaluate the presence of secondary hyperalgesia, mechanical pinprick sensitivity was assessed on the skin surrounding the site where HFS was applied and also on the contralateral arm. RESULTS: HFS induced a significant increase in mechanical pinprick sensitivity on the HFS-treated arm. However, HFS did not decrease PPTs neither in the area of increased pinprick sensitivity nor at more distant sites. CONCLUSION: This study provides no evidence for the hypothesis that CS, induced after intense activation of skin nociceptors, involves a widespread decrease of PPTs. |
format | Online Article Text |
id | pubmed-6344133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-63441332019-01-31 No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors Cayrol, Timothée Pitance, Laurent Roussel, Nathalie Mouraux, André van den Broeke, Emanuel N. Pain Rep General Section INTRODUCTION: An increasing number of clinical studies involving a range of chronic pain conditions report widespread mechanical pressure pain hypersensitivity, which is commonly interpreted as resulting from central sensitization (CS). Secondary hyperalgesia (increased pinprick sensitivity surrounding the site of injury) is considered to be a manifestation of CS. However, it has not been rigorously tested whether CS induced by peripheral nociceptive input involves widespread mechanical pressure pain hypersensitivity. OBJECTIVES: The aim of this study was to assess whether high-frequency electrical stimulation (HFS), which induces a robust secondary hyperalgesia, also induces a widespread decrease of pressure pain thresholds (PPTs). METHODS: We measured PPTs bilaterally on the temples (temporalis muscles), on the legs (tibialis anterior muscles), and on the ventral forearm (flexor carpi radialis muscles) before, 20 minutes after, and 45 minutes after applying HFS on the ventral forearm of sixteen healthy young volunteers. To evaluate the presence of secondary hyperalgesia, mechanical pinprick sensitivity was assessed on the skin surrounding the site where HFS was applied and also on the contralateral arm. RESULTS: HFS induced a significant increase in mechanical pinprick sensitivity on the HFS-treated arm. However, HFS did not decrease PPTs neither in the area of increased pinprick sensitivity nor at more distant sites. CONCLUSION: This study provides no evidence for the hypothesis that CS, induced after intense activation of skin nociceptors, involves a widespread decrease of PPTs. Wolters Kluwer 2018-10-18 /pmc/articles/PMC6344133/ /pubmed/30706036 http://dx.doi.org/10.1097/PR9.0000000000000691 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | General Section Cayrol, Timothée Pitance, Laurent Roussel, Nathalie Mouraux, André van den Broeke, Emanuel N. No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title | No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title_full | No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title_fullStr | No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title_full_unstemmed | No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title_short | No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
title_sort | no evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors |
topic | General Section |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344133/ https://www.ncbi.nlm.nih.gov/pubmed/30706036 http://dx.doi.org/10.1097/PR9.0000000000000691 |
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