Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain

INTRODUCTION: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of cathepsin K, on pain behaviour and joint pathology in a model of OA pain. METHODS: Effects of preventative (30 a...

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Detalles Bibliográficos
Autores principales: Nwosu, Lilian N., Gowler, Peter R.W., Burston, James J., Rizoska, Biljana, Tunblad, Karin, Lindström, Erik, Grabowska, Urszula, Li, Li, McWilliams, Dan F., Walsh, David A., Chapman, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344135/
https://www.ncbi.nlm.nih.gov/pubmed/30706033
http://dx.doi.org/10.1097/PR9.0000000000000685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344135/
https://www.ncbi.nlm.nih.gov/pubmed/30706033
http://dx.doi.org/10.1097/PR9.0000000000000685

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