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Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report
RATIONALE: Due to the anatomical and biological characteristics of nasopharyngeal carcinoma (NPC), radiotherapy is the standard treatment of choice. Recent advances in small molecule therapies targeting tumor angiogenesis also hold promise for the treatment of advanced NPC. PATIENT CONCERNS: The pat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344178/ https://www.ncbi.nlm.nih.gov/pubmed/30608382 http://dx.doi.org/10.1097/MD.0000000000013491 |
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author | Jin, Jun Du, Jiahao Wu, Yanwei |
author_facet | Jin, Jun Du, Jiahao Wu, Yanwei |
author_sort | Jin, Jun |
collection | PubMed |
description | RATIONALE: Due to the anatomical and biological characteristics of nasopharyngeal carcinoma (NPC), radiotherapy is the standard treatment of choice. Recent advances in small molecule therapies targeting tumor angiogenesis also hold promise for the treatment of advanced NPC. PATIENT CONCERNS: The patient's symptoms, including nasal obstruction, nasal bleeding, and headache, reappeared periodically and eventually became so severe that the patient's vision became impaired. In January 2016, the patient presented with blurred vision, diplopia, language impairment, left temporal paralysis, and bilateral eyelid ptosis. DIAGNOSIS: Advanced NPC without metastasis in a 55-year-old man. INTERVENTIONS: The patient refused treatment with radiotherapy or chemotherapy and was treated with Chinese herbal medicines. Following a worsening of symptoms, the patient was subsequently treated with apatinib monotherapy (0.25 g, once daily). OUTCOMES: Symptom improvement, including decreased nasal bleeding and headache, was observed after 1 week of apatinib treatment. After 100 days of treatment, the patient was nearly asymptomatic with stable disease and improved quality of life. LESSONS: For patients with advanced NPC who refuse standard radiotherapy and chemotherapy, apatinib monotherapy may be a suitable treatment option to improve symptoms and quality of life even in those with vascular endothelial growth factor receptor-negative tumors. |
format | Online Article Text |
id | pubmed-6344178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63441782019-02-04 Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report Jin, Jun Du, Jiahao Wu, Yanwei Medicine (Baltimore) Research Article RATIONALE: Due to the anatomical and biological characteristics of nasopharyngeal carcinoma (NPC), radiotherapy is the standard treatment of choice. Recent advances in small molecule therapies targeting tumor angiogenesis also hold promise for the treatment of advanced NPC. PATIENT CONCERNS: The patient's symptoms, including nasal obstruction, nasal bleeding, and headache, reappeared periodically and eventually became so severe that the patient's vision became impaired. In January 2016, the patient presented with blurred vision, diplopia, language impairment, left temporal paralysis, and bilateral eyelid ptosis. DIAGNOSIS: Advanced NPC without metastasis in a 55-year-old man. INTERVENTIONS: The patient refused treatment with radiotherapy or chemotherapy and was treated with Chinese herbal medicines. Following a worsening of symptoms, the patient was subsequently treated with apatinib monotherapy (0.25 g, once daily). OUTCOMES: Symptom improvement, including decreased nasal bleeding and headache, was observed after 1 week of apatinib treatment. After 100 days of treatment, the patient was nearly asymptomatic with stable disease and improved quality of life. LESSONS: For patients with advanced NPC who refuse standard radiotherapy and chemotherapy, apatinib monotherapy may be a suitable treatment option to improve symptoms and quality of life even in those with vascular endothelial growth factor receptor-negative tumors. Wolters Kluwer Health 2019-01-04 /pmc/articles/PMC6344178/ /pubmed/30608382 http://dx.doi.org/10.1097/MD.0000000000013491 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Jin, Jun Du, Jiahao Wu, Yanwei Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title | Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title_full | Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title_fullStr | Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title_full_unstemmed | Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title_short | Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma: A case report |
title_sort | apatinib monotherapy for advanced vegfr-2-negative nasopharyngeal carcinoma: a case report |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344178/ https://www.ncbi.nlm.nih.gov/pubmed/30608382 http://dx.doi.org/10.1097/MD.0000000000013491 |
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