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Identification of B cell epitopes enhanced by protein unfolding and aggregation
Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344229/ https://www.ncbi.nlm.nih.gov/pubmed/30550980 http://dx.doi.org/10.1016/j.molimm.2018.11.020 |