Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes

Alzheimer’s disease (AD), a neurodegenerative diseases (neuro-diseases) which is prevalent in the elderly and seriously affects the lives of individuals. Many studies have discussed the relationship between immune system and AD pathogenesis. Here, the meta-analysis of differentially expressed (DE) g...

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Autores principales: Wang, Nan, Zhang, Ying, Xu, Li, Jin, Shuilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344412/
https://www.ncbi.nlm.nih.gov/pubmed/30705616
http://dx.doi.org/10.3389/fnins.2018.01026
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author Wang, Nan
Zhang, Ying
Xu, Li
Jin, Shuilin
author_facet Wang, Nan
Zhang, Ying
Xu, Li
Jin, Shuilin
author_sort Wang, Nan
collection PubMed
description Alzheimer’s disease (AD), a neurodegenerative diseases (neuro-diseases) which is prevalent in the elderly and seriously affects the lives of individuals. Many studies have discussed the relationship between immune system and AD pathogenesis. Here, the meta-analysis of differentially expressed (DE) genes based on microarray data was conducted to study the association between AD and immune system. 9519 target genes of hippocampus in 146 subjects (73 AD cases and 73 controls) from 4 microarray data sets were compiled and DE genes with p < 1.00E - 04 were selected to conduct the pathway-analysis. The results indicated that the DE genes were significantly enriched in the neuro-diseases as well as the immune system pathways.
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spelling pubmed-63444122019-01-31 Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes Wang, Nan Zhang, Ying Xu, Li Jin, Shuilin Front Neurosci Neuroscience Alzheimer’s disease (AD), a neurodegenerative diseases (neuro-diseases) which is prevalent in the elderly and seriously affects the lives of individuals. Many studies have discussed the relationship between immune system and AD pathogenesis. Here, the meta-analysis of differentially expressed (DE) genes based on microarray data was conducted to study the association between AD and immune system. 9519 target genes of hippocampus in 146 subjects (73 AD cases and 73 controls) from 4 microarray data sets were compiled and DE genes with p < 1.00E - 04 were selected to conduct the pathway-analysis. The results indicated that the DE genes were significantly enriched in the neuro-diseases as well as the immune system pathways. Frontiers Media S.A. 2019-01-17 /pmc/articles/PMC6344412/ /pubmed/30705616 http://dx.doi.org/10.3389/fnins.2018.01026 Text en Copyright © 2019 Wang, Zhang, Xu and Jin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Nan
Zhang, Ying
Xu, Li
Jin, Shuilin
Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title_full Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title_fullStr Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title_full_unstemmed Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title_short Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
title_sort relationship between alzheimer’s disease and the immune system: a meta-analysis of differentially expressed genes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344412/
https://www.ncbi.nlm.nih.gov/pubmed/30705616
http://dx.doi.org/10.3389/fnins.2018.01026
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