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Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (...

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Detalles Bibliográficos
Autores principales:	Yau, Suk-Yu, Bettio, Luis, Chiu, Jason, Chiu, Christine, Christie, Brian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344420/ https://www.ncbi.nlm.nih.gov/pubmed/30705620 http://dx.doi.org/10.3389/fnmol.2018.00495

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