Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative diseases: so called “prion-like” mechanisms. While ex vivo mammalian prions, composed of multichain assemblies of misfolded host-encoded prion pr...

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Detalles Bibliográficos
Autores principales: Terry, Cassandra, Harniman, Robert L., Sells, Jessica, Wenborn, Adam, Joiner, Susan, Saibil, Helen R., Miles, Mervyn J., Collinge, John, Wadsworth, Jonathan D. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344479/
https://www.ncbi.nlm.nih.gov/pubmed/30675000
http://dx.doi.org/10.1038/s41598-018-36700-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344479/
https://www.ncbi.nlm.nih.gov/pubmed/30675000
http://dx.doi.org/10.1038/s41598-018-36700-w

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