Cargando…

Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system

To address the unmet needs for human polyclonal antibodies both as therapeutics and diagnostic reagents, building upon our previously established transchromosomic (Tc) cattle platform, we report herein the development of a Tc goat system expressing human polyclonal antibodies in their sera. In the T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Hua, Fan, Zhiqiang, Brandsrud, Michelle, Meng, Qinggang, Bobbitt, Molly, Regouski, Misha, Stott, Rusty, Sweat, Alexis, Crabtree, Jackelyn, Hogan, Robert J., Tripp, Ralph A., Wang, Zhongde, Polejaeva, Irina A., Sullivan, Eddie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344498/ https://www.ncbi.nlm.nih.gov/pubmed/30675003 http://dx.doi.org/10.1038/s41598-018-36961-5

Ejemplares similares

Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production
por: Matsushita, Hiroaki, et al.
Publicado: (2014)

Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle
por: Dye, John M., et al.
Publicado: (2016)

Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters
por: Siddharthan, Venkatraman, et al.
Publicado: (2019)

Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle
por: Sano, Akiko, et al.
Publicado: (2013)

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System
por: Ni, Wei, et al.
Publicado: (2014)

Correction: Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle
por: Sano, Akiko, et al.
Publicado: (2014)

Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants
por: Gilliland, Theron, et al.
Publicado: (2023)

Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses
por: Bounds, Callie E., et al.
Publicado: (2015)

Polyclonal Antibodies Derived from Transchromosomic Bovines Vaccinated with the Recombinant F1-V Vaccine Increase Bacterial Opsonization In Vitro and Protect Mice from Pneumonic Plague
por: Biryukov, Sergei S., et al.
Publicado: (2023)

Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study
por: Beigel, John H, et al.
Publicado: (2018)

Correction: Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production
Publicado: (2014)

Prevalence and identification of caprine pasteurellosis in pneumonic goats in Bangladesh
por: Rahman, Md. Habibur, et al.
Publicado: (2023)

Contribution of atrial myofiber architecture to atrial fibrillation
por: Kamali, Roya, et al.
Publicado: (2023)

Estimated Prevalence of Caprine Paratuberculosis in Boer Goat Herds in Missouri, USA
por: Pithua, Patrick, et al.
Publicado: (2012)

Molecular characterization of exon 3 of caprine myostatin gene in Marwari goat
por: Khichar, Jai Prakash, et al.
Publicado: (2016)

The Prevalence of Histopathological Features of Pneumonia in Goats with Symptomatic Caprine Arthritis-Encephalitis
por: Moroz, Agata, et al.
Publicado: (2022)

Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines
por: Mucker, Eric M., et al.
Publicado: (2020)

Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle
por: Matsushita, Hiroaki, et al.
Publicado: (2015)

Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics
por: Viotti Perisse, Iuri, et al.
Publicado: (2021)

Activating the Expression of Human K-ras(G12D) Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells
por: Gong, Jianhua, et al.
Publicado: (2014)

Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie
por: Dassanayake, Rohana P., et al.
Publicado: (2015)

Diversity of Astrovirus in Goats in Southwest China and Identification of Two Novel Caprine Astroviruses
por: Wang, Jiayi, et al.
Publicado: (2022)

Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling
por: Davies, Christopher J., et al.
Publicado: (2022)

Ovine and Caprine Brucellosis (Brucella melitensis) in Aborted Animals in Jordanian Sheep and Goat Flocks
por: Samadi, Assadullah, et al.
Publicado: (2010)

Ultrasonographic findings in goats with contagious caprine pleuropneumonia caused by Mycoplasma capricolum subsp. capripneumoniae
por: Tharwat, Mohamed, et al.
Publicado: (2017)

First study on the molecular prevalence of caprine arthritis encephalitis virus in goats in Babylon, Iraq
por: Mosa, Ahmed Hamzah, et al.
Publicado: (2022)

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants
por: Liu, Zhuoming, et al.
Publicado: (2021)

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse
por: Dunlevy, Louisa, et al.
Publicado: (2010)

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice
por: Shinohara, Takashi, et al.
Publicado: (2017)

Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models
por: Perley, Casey C., et al.
Publicado: (2020)

Goat uterine epithelial cells are susceptible to infection with Caprine Arthritis Encephalitis Virus (CAEV) in vivo
por: Ali Al Ahmad, Mohamad Z, et al.
Publicado: (2012)

Detection of Caprine-specific Nucleic Acid Sequences in Goat Milk Using Polymerase Chain Reaction
por: Osman, Asim A., et al.
Publicado: (2013)

First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France
por: Suavet, Florence, et al.
Publicado: (2016)

Case Report: A Case of Caprine Arthritis Encephalitis in Dairy Goat Farms in South Korea
por: Son, Ga-In, et al.
Publicado: (2021)

Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate
por: Luke, Thomas, et al.
Publicado: (2018)

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom
por: Goldmann, Wilfred, et al.
Publicado: (2011)

Development and Evaluation of Epitope-Blocking ELISA for Detection of Antibodies against Contagious Caprine Pleuropneumonia in Goat Sera
por: Jean de Dieu, Baziki, et al.
Publicado: (2019)

Seroprevalence of Peste des Petits Ruminants and Contagious Caprine Pleuropneumonia Coinfections in Goats in Kwale County, Kenya
por: Lugonzo, George, et al.
Publicado: (2023)

Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix
por: Delom, Frédéric, et al.
Publicado: (2009)

Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation
por: Yoshimura, Yuki, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sd9sp1r18rdvdoi3kdmggpimdn