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Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells

Transcriptome data on the quantitative numbers of transcriptional variants expressed in primary cells offer essential clues into specific cellular functions and biological processes. We have previously collected transcriptomes from primary smooth muscle cells (SMC), interstitial cells of Cajal (ICC)...

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Autores principales: Breland, Adrienne, Ha, Se Eun, Jorgensen, Brian G., Jin, Byungchang, Gardner, Treg A., Sanders, Kenton M., Ro, Seungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344548/
https://www.ncbi.nlm.nih.gov/pubmed/30674925
http://dx.doi.org/10.1038/s41598-018-36607-6
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author Breland, Adrienne
Ha, Se Eun
Jorgensen, Brian G.
Jin, Byungchang
Gardner, Treg A.
Sanders, Kenton M.
Ro, Seungil
author_facet Breland, Adrienne
Ha, Se Eun
Jorgensen, Brian G.
Jin, Byungchang
Gardner, Treg A.
Sanders, Kenton M.
Ro, Seungil
author_sort Breland, Adrienne
collection PubMed
description Transcriptome data on the quantitative numbers of transcriptional variants expressed in primary cells offer essential clues into specific cellular functions and biological processes. We have previously collected transcriptomes from primary smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and PDGFRα(+) cells (fibroblast-like cells) isolated from murine jejunal and colonic smooth muscle and/or mucosal tissues as well as transcriptomes from the associated tissues (jejunal smooth muscle, colonic smooth muscle, and colonic mucosa). In this study, we have built the Smooth Muscle Transcriptome Browser (SMTB), https://med.unr.edu/physio/transcriptome, a web-based, graphical user interface that offers genetic references and expression profiles of all transcripts expressed at both the cellular (SMC, ICC, and PDGFRα(+) cells) and tissue level (smooth muscle and mucosal tissue). This browser brings new insights into the cellular and biological functions of the cell types in gastrointestinal smooth muscle biology.
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spelling pubmed-63445482019-01-28 Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells Breland, Adrienne Ha, Se Eun Jorgensen, Brian G. Jin, Byungchang Gardner, Treg A. Sanders, Kenton M. Ro, Seungil Sci Rep Article Transcriptome data on the quantitative numbers of transcriptional variants expressed in primary cells offer essential clues into specific cellular functions and biological processes. We have previously collected transcriptomes from primary smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and PDGFRα(+) cells (fibroblast-like cells) isolated from murine jejunal and colonic smooth muscle and/or mucosal tissues as well as transcriptomes from the associated tissues (jejunal smooth muscle, colonic smooth muscle, and colonic mucosa). In this study, we have built the Smooth Muscle Transcriptome Browser (SMTB), https://med.unr.edu/physio/transcriptome, a web-based, graphical user interface that offers genetic references and expression profiles of all transcripts expressed at both the cellular (SMC, ICC, and PDGFRα(+) cells) and tissue level (smooth muscle and mucosal tissue). This browser brings new insights into the cellular and biological functions of the cell types in gastrointestinal smooth muscle biology. Nature Publishing Group UK 2019-01-23 /pmc/articles/PMC6344548/ /pubmed/30674925 http://dx.doi.org/10.1038/s41598-018-36607-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Breland, Adrienne
Ha, Se Eun
Jorgensen, Brian G.
Jin, Byungchang
Gardner, Treg A.
Sanders, Kenton M.
Ro, Seungil
Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title_full Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title_fullStr Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title_full_unstemmed Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title_short Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα(+) cells
title_sort smooth muscle transcriptome browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal smc, icc, and pdgfrα(+) cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344548/
https://www.ncbi.nlm.nih.gov/pubmed/30674925
http://dx.doi.org/10.1038/s41598-018-36607-6
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