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PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms

BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. METHODS: A tota...

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Autores principales: Lee, Ji Hyun, Kang, Hye Ju, Yoo, Chong Woo, Park, Weon Seo, Ryu, Jun Sun, Jung, Yuh-Seog, Choi, Sung Weon, Park, Joo Yong, Han, Nayoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344797/
https://www.ncbi.nlm.nih.gov/pubmed/30424592
http://dx.doi.org/10.4132/jptm.2018.10.12
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author Lee, Ji Hyun
Kang, Hye Ju
Yoo, Chong Woo
Park, Weon Seo
Ryu, Jun Sun
Jung, Yuh-Seog
Choi, Sung Weon
Park, Joo Yong
Han, Nayoung
author_facet Lee, Ji Hyun
Kang, Hye Ju
Yoo, Chong Woo
Park, Weon Seo
Ryu, Jun Sun
Jung, Yuh-Seog
Choi, Sung Weon
Park, Joo Yong
Han, Nayoung
author_sort Lee, Ji Hyun
collection PubMed
description BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. METHODS: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Immunohistochemical staining of PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays. RESULTS: Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showed nuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphic adenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary gland neoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors. Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%) malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and one myoepithelial carcinoma with focal AdCC-like histology. CONCLUSIONS: PLAG1 expression is specific to pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor, but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology is unclear in the surgical specimen.
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spelling pubmed-63447972019-01-30 PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms Lee, Ji Hyun Kang, Hye Ju Yoo, Chong Woo Park, Weon Seo Ryu, Jun Sun Jung, Yuh-Seog Choi, Sung Weon Park, Joo Yong Han, Nayoung J Pathol Transl Med Original Article BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. METHODS: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Immunohistochemical staining of PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays. RESULTS: Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showed nuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphic adenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary gland neoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors. Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%) malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and one myoepithelial carcinoma with focal AdCC-like histology. CONCLUSIONS: PLAG1 expression is specific to pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor, but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology is unclear in the surgical specimen. The Korean Society of Pathologists and the Korean Society for Cytopathology 2019-01 2018-11-14 /pmc/articles/PMC6344797/ /pubmed/30424592 http://dx.doi.org/10.4132/jptm.2018.10.12 Text en © 2019 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Ji Hyun
Kang, Hye Ju
Yoo, Chong Woo
Park, Weon Seo
Ryu, Jun Sun
Jung, Yuh-Seog
Choi, Sung Weon
Park, Joo Yong
Han, Nayoung
PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title_full PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title_fullStr PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title_full_unstemmed PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title_short PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
title_sort plag1, sox10, and myb expression in benign and malignant salivary gland neoplasms
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344797/
https://www.ncbi.nlm.nih.gov/pubmed/30424592
http://dx.doi.org/10.4132/jptm.2018.10.12
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