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Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and mul...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344836/ https://www.ncbi.nlm.nih.gov/pubmed/30670140 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703 |
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author | Ung, Aymeric Baidjoe, Amrish Y. Van Cauteren, Dieter Fawal, Nizar Fabre, Laetitia Guerrisi, Caroline Danis, Kostas Morand, Anne Donguy, Marie-Pierre Lucas, Etienne Rossignol, Louise Lefèvre, Sophie Vignaud, Marie-Léone Cadel-Six, Sabrina Lailler, Renaud Jourdan-Da Silva, Nathalie Le Hello, Simon |
author_facet | Ung, Aymeric Baidjoe, Amrish Y. Van Cauteren, Dieter Fawal, Nizar Fabre, Laetitia Guerrisi, Caroline Danis, Kostas Morand, Anne Donguy, Marie-Pierre Lucas, Etienne Rossignol, Louise Lefèvre, Sophie Vignaud, Marie-Léone Cadel-Six, Sabrina Lailler, Renaud Jourdan-Da Silva, Nathalie Le Hello, Simon |
author_sort | Ung, Aymeric |
collection | PubMed |
description | On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and multilocus variable-number tandem repeat analysis (MLVA) were performed to identify microbiological clusters and links among cases, animal and food sources. Clusters were defined as isolates with less than 15 single nucleotide polymorphisms determined by WGS and/or with identical MLVA pattern. We compared different clusters of cases with other cases (case–case study) and controls recruited from a web-based cohort (case–control study) in terms of food consumption. We interviewed 63/83 (76%) cases; 2,914 controls completed a questionnaire. Both studies’ findings indicated that successive S. Dublin outbreaks from different sources had occurred between November 2015 and March 2016. In the case–control study, cases of distinct WGS clusters were more likely to have consumed Morbier (adjusted odds ratio (aOR): 14; 95% confidence interval (CI): 4.8–42) or Vacherin Mont d’Or (aOR: 27; 95% CI: 6.8–105), two bovine raw-milk cheeses. Based on these results, the Ministry of Agriculture launched a reinforced control plan for processing plants of raw-milk cheeses in the production region, to prevent future outbreaks. |
format | Online Article Text |
id | pubmed-6344836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-63448362019-02-11 Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 Ung, Aymeric Baidjoe, Amrish Y. Van Cauteren, Dieter Fawal, Nizar Fabre, Laetitia Guerrisi, Caroline Danis, Kostas Morand, Anne Donguy, Marie-Pierre Lucas, Etienne Rossignol, Louise Lefèvre, Sophie Vignaud, Marie-Léone Cadel-Six, Sabrina Lailler, Renaud Jourdan-Da Silva, Nathalie Le Hello, Simon Euro Surveill Outbreaks On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and multilocus variable-number tandem repeat analysis (MLVA) were performed to identify microbiological clusters and links among cases, animal and food sources. Clusters were defined as isolates with less than 15 single nucleotide polymorphisms determined by WGS and/or with identical MLVA pattern. We compared different clusters of cases with other cases (case–case study) and controls recruited from a web-based cohort (case–control study) in terms of food consumption. We interviewed 63/83 (76%) cases; 2,914 controls completed a questionnaire. Both studies’ findings indicated that successive S. Dublin outbreaks from different sources had occurred between November 2015 and March 2016. In the case–control study, cases of distinct WGS clusters were more likely to have consumed Morbier (adjusted odds ratio (aOR): 14; 95% confidence interval (CI): 4.8–42) or Vacherin Mont d’Or (aOR: 27; 95% CI: 6.8–105), two bovine raw-milk cheeses. Based on these results, the Ministry of Agriculture launched a reinforced control plan for processing plants of raw-milk cheeses in the production region, to prevent future outbreaks. European Centre for Disease Prevention and Control (ECDC) 2019-01-17 /pmc/articles/PMC6344836/ /pubmed/30670140 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Outbreaks Ung, Aymeric Baidjoe, Amrish Y. Van Cauteren, Dieter Fawal, Nizar Fabre, Laetitia Guerrisi, Caroline Danis, Kostas Morand, Anne Donguy, Marie-Pierre Lucas, Etienne Rossignol, Louise Lefèvre, Sophie Vignaud, Marie-Léone Cadel-Six, Sabrina Lailler, Renaud Jourdan-Da Silva, Nathalie Le Hello, Simon Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title | Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title_full | Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title_fullStr | Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title_full_unstemmed | Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title_short | Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 |
title_sort | disentangling a complex nationwide salmonella dublin outbreak associated with raw-milk cheese consumption, france, 2015 to 2016 |
topic | Outbreaks |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344836/ https://www.ncbi.nlm.nih.gov/pubmed/30670140 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703 |
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