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Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016

On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and mul...

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Autores principales: Ung, Aymeric, Baidjoe, Amrish Y., Van Cauteren, Dieter, Fawal, Nizar, Fabre, Laetitia, Guerrisi, Caroline, Danis, Kostas, Morand, Anne, Donguy, Marie-Pierre, Lucas, Etienne, Rossignol, Louise, Lefèvre, Sophie, Vignaud, Marie-Léone, Cadel-Six, Sabrina, Lailler, Renaud, Jourdan-Da Silva, Nathalie, Le Hello, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344836/
https://www.ncbi.nlm.nih.gov/pubmed/30670140
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703
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author Ung, Aymeric
Baidjoe, Amrish Y.
Van Cauteren, Dieter
Fawal, Nizar
Fabre, Laetitia
Guerrisi, Caroline
Danis, Kostas
Morand, Anne
Donguy, Marie-Pierre
Lucas, Etienne
Rossignol, Louise
Lefèvre, Sophie
Vignaud, Marie-Léone
Cadel-Six, Sabrina
Lailler, Renaud
Jourdan-Da Silva, Nathalie
Le Hello, Simon
author_facet Ung, Aymeric
Baidjoe, Amrish Y.
Van Cauteren, Dieter
Fawal, Nizar
Fabre, Laetitia
Guerrisi, Caroline
Danis, Kostas
Morand, Anne
Donguy, Marie-Pierre
Lucas, Etienne
Rossignol, Louise
Lefèvre, Sophie
Vignaud, Marie-Léone
Cadel-Six, Sabrina
Lailler, Renaud
Jourdan-Da Silva, Nathalie
Le Hello, Simon
author_sort Ung, Aymeric
collection PubMed
description On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and multilocus variable-number tandem repeat analysis (MLVA) were performed to identify microbiological clusters and links among cases, animal and food sources. Clusters were defined as isolates with less than 15 single nucleotide polymorphisms determined by WGS and/or with identical MLVA pattern. We compared different clusters of cases with other cases (case–case study) and controls recruited from a web-based cohort (case–control study) in terms of food consumption. We interviewed 63/83 (76%) cases; 2,914 controls completed a questionnaire. Both studies’ findings indicated that successive S. Dublin outbreaks from different sources had occurred between November 2015 and March 2016. In the case–control study, cases of distinct WGS clusters were more likely to have consumed Morbier (adjusted odds ratio (aOR): 14; 95% confidence interval (CI): 4.8–42) or Vacherin Mont d’Or (aOR: 27; 95% CI: 6.8–105), two bovine raw-milk cheeses. Based on these results, the Ministry of Agriculture launched a reinforced control plan for processing plants of raw-milk cheeses in the production region, to prevent future outbreaks.
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spelling pubmed-63448362019-02-11 Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016 Ung, Aymeric Baidjoe, Amrish Y. Van Cauteren, Dieter Fawal, Nizar Fabre, Laetitia Guerrisi, Caroline Danis, Kostas Morand, Anne Donguy, Marie-Pierre Lucas, Etienne Rossignol, Louise Lefèvre, Sophie Vignaud, Marie-Léone Cadel-Six, Sabrina Lailler, Renaud Jourdan-Da Silva, Nathalie Le Hello, Simon Euro Surveill Outbreaks On 18 January 2016, the French National Reference Centre for Salmonella reported to Santé publique France an excess of Salmonella enterica serotype Dublin (S. Dublin) infections. We investigated to identify the source of infection and implement control measures. Whole genome sequencing (WGS) and multilocus variable-number tandem repeat analysis (MLVA) were performed to identify microbiological clusters and links among cases, animal and food sources. Clusters were defined as isolates with less than 15 single nucleotide polymorphisms determined by WGS and/or with identical MLVA pattern. We compared different clusters of cases with other cases (case–case study) and controls recruited from a web-based cohort (case–control study) in terms of food consumption. We interviewed 63/83 (76%) cases; 2,914 controls completed a questionnaire. Both studies’ findings indicated that successive S. Dublin outbreaks from different sources had occurred between November 2015 and March 2016. In the case–control study, cases of distinct WGS clusters were more likely to have consumed Morbier (adjusted odds ratio (aOR): 14; 95% confidence interval (CI): 4.8–42) or Vacherin Mont d’Or (aOR: 27; 95% CI: 6.8–105), two bovine raw-milk cheeses. Based on these results, the Ministry of Agriculture launched a reinforced control plan for processing plants of raw-milk cheeses in the production region, to prevent future outbreaks. European Centre for Disease Prevention and Control (ECDC) 2019-01-17 /pmc/articles/PMC6344836/ /pubmed/30670140 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Outbreaks
Ung, Aymeric
Baidjoe, Amrish Y.
Van Cauteren, Dieter
Fawal, Nizar
Fabre, Laetitia
Guerrisi, Caroline
Danis, Kostas
Morand, Anne
Donguy, Marie-Pierre
Lucas, Etienne
Rossignol, Louise
Lefèvre, Sophie
Vignaud, Marie-Léone
Cadel-Six, Sabrina
Lailler, Renaud
Jourdan-Da Silva, Nathalie
Le Hello, Simon
Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title_full Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title_fullStr Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title_full_unstemmed Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title_short Disentangling a complex nationwide Salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016
title_sort disentangling a complex nationwide salmonella dublin outbreak associated with raw-milk cheese consumption, france, 2015 to 2016
topic Outbreaks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344836/
https://www.ncbi.nlm.nih.gov/pubmed/30670140
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1700703
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