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Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018
The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in De...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344841/ https://www.ncbi.nlm.nih.gov/pubmed/30670142 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1800698 |
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| author | Takashita, Emi Kawakami, Chiharu Morita, Hiroko Ogawa, Rie Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato |
| author_facet | Takashita, Emi Kawakami, Chiharu Morita, Hiroko Ogawa, Rie Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato |
| author_sort | Takashita, Emi |
| collection | PubMed |
| description | The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in December 2018. This mutation is known to confer reduced susceptibility to baloxavir, and the two mutant viruses exhibited 76- and 120-fold reduced susceptibility to baloxavir. |
| format | Online Article Text |
| id | pubmed-6344841 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63448412019-02-11 Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 Takashita, Emi Kawakami, Chiharu Morita, Hiroko Ogawa, Rie Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato Euro Surveill Rapid Communication The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in December 2018. This mutation is known to confer reduced susceptibility to baloxavir, and the two mutant viruses exhibited 76- and 120-fold reduced susceptibility to baloxavir. European Centre for Disease Prevention and Control (ECDC) 2019-01-17 /pmc/articles/PMC6344841/ /pubmed/30670142 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1800698 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Takashita, Emi Kawakami, Chiharu Morita, Hiroko Ogawa, Rie Fujisaki, Seiichiro Shirakura, Masayuki Miura, Hideka Nakamura, Kazuya Kishida, Noriko Kuwahara, Tomoko Mitamura, Keiko Abe, Takashi Ichikawa, Masataka Yamazaki, Masahiko Watanabe, Shinji Odagiri, Takato Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title | Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title_full | Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title_fullStr | Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title_full_unstemmed | Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title_short | Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018 |
| title_sort | detection of influenza a(h3n2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in japan, december 2018 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344841/ https://www.ncbi.nlm.nih.gov/pubmed/30670142 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.3.1800698 |
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